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| An Analysis of the Effects of Repetitive Transcranial Magnetic Stimulation on Cognitive Function and Serum Pro-Inflammatory Cytokines in Patients with Post-Traumatic Stress Disorder |
| LI Yang, WANG Xue, et al |
| Beijing Anding Hospital Affiliated to Capital Medical University, Beijing 100088, China |
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Abstract Objective: To investigate the effects of repetitive transcranial magnetic stimulation (rTMS) on cognitive function and serum pro-inflammatory cytokines in patients with post-traumatic stress disorder (PTSD). Methods: 96 patients with PTSD were randomly divided into low frequency treatment group, high frequency treatment group and sham stimulation group, 32 cases in each group. For the low-frequency and high-frequency treatment groups, 0.5 Hz and 10 Hz rTMS were given to the right dorsolateral frontal lobe respectively. In the sham stimulation group, no current, but current sound, was given. The treatment lasted for 3 weeks. The clinical symptoms and cognitive functions of patients in the three groups were evaluated by PCL-C and MoCA scales, meanwhile, the serum levels of interleukin-2(IL-2), interleukin-6 (IL-6) and tumor necrosis factor (TNF-α) were measured by enzyme-linked immunosorbent assay (ELISA) one day before treatment and three weeks after treatment. Results: Before treatment, the indexes of the three groups were comparable. After treatment, the scores of PCL-C scale in the low-frequency and high-frequency treatment groups were lower than those in the sham-stimulation group, and the scores of MoCA scale were higher than those in the sham-stimulation group; the levels of IL-2, IL-6 and TNF-a in the low-frequency and high-frequency treatment groups were lower than those in the sham-stimulation group. The difference was statistically significant (P<0.05). In addition, serum levels of IL-2, IL-6 and TNF-a were negatively correlated with total scores and factor scores of MoCA scale. But there was no significant difference in the above aspects between the low-frequency and high-frequency treatment groups (P>0.05). Conclusions: It's proved that rTMS could effectively improve the cognitive impairment of PTSD patients, which may be achieved by inhibiting the secretion of pro-inflammatory factors in serum.
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2020, Vol. 26 
