G试验和GM试验联合检测对恶性血液病患者侵袭性真菌感染的诊断价值

doi:10.3969/j.issn.1006-6233.2020.06.015

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Abstract Objective: To explore diagnostic value of combined detection of (1,3)-β-D-glucan (G test) and galactomannan antigen (GM test) for invasive fungal infections (IFI) in patients with hematologic malignancies. Methods: A total of 178 patients with hematologic malignancies who were admitted to the hospital from June 2018 to June 2019 were enrolled. According to traditional clinical diagnosis results, they were divided into IFI group (50 cases) and non-IFI group (128 cases). All underwent G test and GM test. The receiver operating characteristic (ROC) curves were applied to analyze critical values of G test and GM test. The value of G test, GM test and their combination for diagnosis of IFI and diagnosis time were analyzed. Results: ROC curve analysis showed that critical values of G test and GM test were 147.37 pg/mL and 0.88 ug/L, respectively. Compared with G test alone or GM test alone, sensitivity of combined diagnosis for IFI was significantly improved (P<0.05). Compared with clinical diagnosis, G test, GM test and their combination can shorten IFI diagnosis time (P<0.05). Conclusion: The combined detection of G test and GM test can effectively improve diagnostic sensitivity of patients with hematologic malignancies and IFI, and shorten waiting time of diagnosis.

Key words： G test GM test Hematologic malignancy Invasive fungal infection Diagnostic value

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.06.015 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I6/951

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