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| Efficacy of Mosapride Combined with Traditional Chinese Medicine Sticking to Shenque Acupoint in the Treatment of Functional in the Elderly and its Effects on Serum NO and SP Levels |
| YAN Xiaochun, et al |
| West China Guang'an Hospital, Sichuan University, Sichuan Guang'an 638500, China |
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Abstract Objective: To explore the efficacy of mosapride combined with traditional Chinese medicine sticking to Shenque acupoint in the treatment of functional constipation (FC) in the elderly and its effects on serum enteric neurotransmitters and quality of life. Methods: A total of 106 elderly patients with FC who were admitted to gastroenterology department of our hospital from June 2018 to June 2019 were selected and randomly divided into observation group (n=53) and control group (n=53). Control group was treated with mosapride, and observation group was given traditional Chinese medicine sticking to Shenque acupoint besides mosapride. The clinical efficacy, total colonic transit time and segmental colonic transit time were compared between the two groups. Serum intestinal neurotransmitters [nitric oxide (NO), substance P (SP), vasoactive intestinal peptide (VIP)], daily defecation time, weekly defecation frequency, abdominal pain [visual analogue scale (VAS)], stool traits [Bristol stool trait scale] and quality of life [quality of life questionnaire of patients with constipation (PAC-QOL)] before and after treatment were observed. Results: The total effective rate of treatment in observation group was higher than that in control group (P<0.05), and the transit time of right hemicolon, sigmoid rectum, left hemicolon and total colon were lower than those in control group (P<0.05). After 4 weeks of treatment, the levels of serum NO and VIP and PAC-QOL scale score in observation group were lower than those in control group (P<0.05) while the SP level was higher than that in control group (P<0.05), and the differences before and after treatment in observation group were larger than those in control group (P<0.05). After 4 weeks of treatment, the daily defecation time was shortened, and the weekly defecation frequency was increased, and the abdominal pain VAS score was decreased and the Bristol score was increased in observation group compared with those in control group (P<0.05), and the differences before and after treatment in observation group were larger than those in control group (P<0.05). Conclusion: On the basis of mosapride for elderly FC, traditional Chinese medicine sticking on Shenque acupoint has good treatment effects. It can promote intestinal function recovery and improve prognosis and quality of life by regulating intestinal neurotransmitters levels.
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[1] 黄林生,祝琦,高仁元,等.合生元治疗慢性功能性便秘的疗效及对肠道菌群结构的影响研究[J].中国全科医学,2018,21(8):908~913.
[2] 邓罡,徐丽姝,覃铁和.老年功能性便秘患者盆底表面肌电特征及生物反馈治疗[J].实用医学杂志,2018,34(8):1316~1319.
[3] 王凤笑,王文秀,周悦,等.针刺“精宫”、中极穴配合神阙穴穴位贴敷治疗小儿神经性尿频31例[J].中国针灸,2019,39(7):771~772.
[4] 中华医学会消化病学分会胃肠动力学组,中华医学会外科学分会结直肠肛门外科学组.中国慢性便秘诊治指南(2013年,武汉)[J].中华消化杂志,2013,33(5):291~297.
[5] 中华人民共和国卫生部.中药新药临床研究指导原则[M].第1辑.北京:人民卫生出版社,1993.131~133.
[6] 徐城,杨晓秋,刘丹彦.常用的疼痛评估方法在临床疼痛评估中的作用[J].中国疼痛医学杂志,2015,21(3):210~212.
[7] 吕建琴,王成伟,刘梦阅,等.电针深刺对功能性便秘患者排便次数及大便性状的影响[J].针刺研究,2017,42(3):254~258.
[8] 赵贞贞,林征,林琳,等.中文版患者便秘状况评估量表在应用评价中的信效度研究[J].中华护理杂志,2010,45(12):1124~1126.
[9] 钟景页,程双平,姚欣,等.枸橼酸莫沙必利联合乳果糖治疗老年难治性功能性便秘临床效果观察[J].临床误诊误治,2018,31(11):30~33.
[10] 田刚,吴冰,王艳春,等.酪酸梭菌肠球菌三联活菌片联合莫沙必利治疗老年功能性便秘的疗效观察[J].广西医学,2019,41(1):108~109,118.
[11] 隋楠,田振国.田振国“从气治秘”调畅情志治疗慢性功能性便秘经验总结[J].辽宁中医杂志,2018,45(4):689~691. |
| [1] |
. [J]. HeBei Med, 2017, 23(7): 1166-1169. |
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2020, Vol. 26 
