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| Observation on the Effect of Propofol Combined with Dizosin and Different Doses of Naborphine in Painless Gastroscopy |
| ZHU Heye, ZENG Weiyun, XU Xia, et al |
| Sanya Central Hospital / The Third People's Hospital of Hainan Province, Hainan Sanya 572000, China |
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Abstract Objective: To investigate the effects of propofol combined with dizocine and different doses of nalbuphine in painless gastroenteroscopy. Methods: From April 2018 to April 2019, 117 patients undergoing gastroenteroscopy in our hospital were selected for prospective randomized controlled study. According to simple random number table method, the patients were divided into propofol combined with dizosin (n=39, group A), propofol combined with low-dose nabuchin (n=39, group B), propofol combined with high-dose nabuchin (n=39, group C). The vital signs, postoperative propofol dosage, pain, cognitive score, biochemical index and perioperative complications were compared among the three groups. Results: The vital sign parameters of three groups changed with time (f time point = 240.772, 542.149, 47.940, 70.877, P<0.05), and the systolic pressure (SBP), diastolic pressure (DBP), pulse oxygen saturation (SpO2), heart rate (HR) of three groups were significantly lower than t0 (P<0.05), and there was no significant difference between the three groups at the same time point (P>0.05). There were significant differences in propofol dosage, NRS score and serum biochemical indexes among the three groups (F=349.433, 56.720, 45.245, 136.645, 98.352, 29.738, P<0.05), and propofol dosage, NRS score and serum biochemical indexes in group C were significantly lower than those in group A and group B (P<0.05), while those in group B were significantly lower than those in group A (P<0.05). The incidence of complications in group C was significantly lower than that in group A (P<0.05), and there was no significant difference between group C and group B (P>0.05). Conclusion: In painless gastroscopy, the effect of propofol combined with high dose of nabufine is better than that of low dose of nabufine, which is significantly higher than that of propofol combined with dizosin.
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2020, Vol. 26 
