腹腔镜手术与开腹手术对结肠癌患者创伤应激及预后的影响

doi:10.3969/j.issn.1006-6233.2020.05.028

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Abstract Objective: To analyze the influence of laparoscopy and laparotomy on the trauma stress and prognosis of colon cancer patients. Methods: 96 patients with colorectal cancer admitted to the hospital from August 2012 to March 2015 were selected for study. They were divided into minimally invasive group (laparoscopic surgery)and open surgery group(open surgery) according to simple random grouping method. The operation related indexes, trauma stress indexes, complications and prognosis related indexes of the two groups were compared. Results: In the minimally invasive group, the bleeding volume was lower than that in the open group, the incision length was shorter than that in the open group, and the anal recovery time was earlier than that in the open group (P<0.05). There was no significant difference between the two groups in operation time, lymphadenectomy and hospitalization time (P>0.05). The levels of aldosterone, cortisol and adrenaline in the minimally invasive group were lower than those in the open group on the 1st, 3rd and 5th day after operation (P<0.05). There was no significant difference in the total incidence of complications and the incidence of different types of complications between the two groups (P>0.05). One case of anastomotic leakage and two cases of intestinal obstruction in the open group were cured by operation, and the other complications improved after conservative treatment. There was no significant difference in the follow-up time between the two groups (P>0.05), 5 patients in the minimally invasive group lost the visit, 9 patients in the open group lost the visit. There was no significant difference in 5-year local recurrence rate, distant metastasis rate, overall survival rate and tumor free survival rate between the two groups (P>0.05). Conclusion: The prognosis of laparoscopic surgery for colon cancer is similar to that of open surgery, but the trauma stress caused by surgery is less

Key words： Colon cancer Laparotomy Laparoscopic surgery Radical surgery Prognosis Trauma Stress response

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.05.028 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I5/815

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