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| Analysis of the Clinical Effect of Medloratadine Combined with Endoscopic Sinus Surgery on Chronic Sinusitis and the Improvement of Allergy and Olfactory Function |
| LI Jun |
| The People's Hospital of Danzhou City, Hainan Danzhou 571700, China |
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Abstract Objective: To analyze the clinical effect of medloratadine combined with endoscopic sinus surgery on chronic sinusitis and the improvement of allergy and olfactory function. Methods: 79 chronic sinusitis patients who received therapy from March 2017 to February 2018 were selected as research objects and divided into the observation group (n=41) and the control group (n=38) with simple random grouping method. The control group was given endoscopic sinus surgery, and the observation group was treated with medloratadine on the basis of the control group. The control group was given endoscopic sinus surgery, and the observation group was treated with medloratadine on the basis of the control group. The post-treatment comparison was made between both groups on treatment efficacy, smell, Lund-Mackay, Lund-Kennedy scores, allergy, and inflammation. Results: The post-treatment evaluation reveals that, in comparison with the control group, the total effective rate of observation group was significantly higher [92.68％(38/41)vs68.42%(26/38)](P＜0.05＝; smell, Lund-Mackay and Lund-Kennedy scores were significantly lower [(2.51±0.70)scores vs(4.03±0.92)scores,(4.32±0.51)scores vs(6.56±0.83)scores,(2.46±0.12)scores vs(4.03±0.26)scores] (P＜0.05); serum TIgE and ECP were significantly lower [(57.98±4.91)kU/L vs(63.75±7.02)kU/L,(4.02±0.50)ng/L vs(5.38±0.92)ng/L] (P＜0.05); serum levels of TNF-alpha, IL-6 and IL-8 were significantly lower [(1.19±0.52)ng/ml vs(2.70±0.81)ng/ml,(5.10±1.05)pg/ml vs(10.26±2.01)pg/ml,(281.96±30.49)ng/L vs(316.30±42.80)ng/L](P＜0.05).Conclusion:Medloratadine combined with endoscopic sinus surgery can alleviate the clinical symptoms, improve the ventilation function of the nasal cavity and sinuses, restore the olfactory function, reduce the allergic reaction, promote the recovery, and the treatment effect is significant.
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2020, Vol. 26 
