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| Clinical Significance and Changes of Serum IL-17 IL-6 and TIMP-2 Levels in Elderly Patients with Inguinal Hernia Before and After Tension-Free Hernioplasty |
| SHI Xuesong, CAO Hongyong, XIAO Hua |
| Nanjing Hospital Affiliated to Nanjing Medical University, Jiangsu Nanjing 210006, China |
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Abstract Objective: To observe the changes in levels of serum interleukin-17 (IL-17), interleukin-6 (IL-6) and tissue inhibitor of metalloproteinase (TIMP-2) of elderly patients with inguinal hernia (IH) before and after tension-free hernioplasty (TFH), and to analyze their clinical significance. Methods: 96 elderly IH patients in the hospital who had undergone TFH were enrolled as observation group, and 47 healthy controls in the same period were enrolled as control group. The levels of serum IL-17, IL-6 and TIMP-2 before and after surgery in the observation group were compared with those in the control group. According to different postoperative complications and recurrence, the patients were divided into good prognosis group and poor prognosis group. The levels of serum IL-17, IL-6 and TIMP-2 were compared between the two groups and control group and correlation analysis was conducted. Results: The levels of serum IL-17 and IL-6 after surgery were higher than those before surgery, which were higher than those in control group (P<0.05). Arranging levels of serum IL-17 and IL-6 from low to high, the corresponding order was control group, good prognosis group and poor prognosis group (P<0.05). TIMP-2 level after surgery was lower than that before surgery, which was lower than that in control group (P<0.05). TIMP-2 level was the highest in control group, followed by good prognosis group and poor prognosis group (P<0.05). Serum IL-17 and IL-6 were negatively correlated with prognosis of elderly IH patients undergoing TFH (P<0.05), while serum TIMP-2 was positively correlated with prognosis (P<0.05). Conclusion: Compared with those before surgery, at 24h after surgery, levels of serum IL-17 and IL-6 are significantly increased in elderly IH patients who have undergone TFH, while serum TIMP-2 level is significantly decreased. Their changes are closely related to prognosis, which can provide effective guidance for clinical treatment and prognosis assessment.
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2020, Vol. 26 
