血清S-100β与老年急性脑梗死患者非快速眼动期睡眠障碍及认知功能关系的临床分析

doi:10.3969/j.issn.1006-6233.2020.04.023

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Abstract Objective: To study the relationship between serum S-100 β and sleep disorder and cognitive function sleep in elderly patients with acute cerebral infarction. Methods: 216 elderly patients with acute cerebral infarction admitted to our hospital from May 2015 to May 2019 were divided into group A (with non-rapid eye movement sleep disorder, 112 cases) and group B (without non-rapid eye movement sleep disorder, 104 cases).All patients accept guide more sleep monitoring, compared two groups of total sleep time (TST), sleep latency (SOL), number of awakening (WUT), sleep efficiency (SE) and rapid eye movement (REM) sleep period (REMT), REM sleep time period of total sleep time percentage(REM%) sleep and non-rem sleep (NREM) sleep stage S1, S2, S3 + S4 sleep time.Montreal Cognitive Assessment Scale (MOCA) was used to assess the cognitive function of the two groups. Serum S-100beta level and its relationship with sleep parameters and cognitive function were analyzed. Results: The sleep time of TST, SE, REMT, REM% and NREM in group A was significantly lower than that in group B (P<0.05), while the sleep time of SOL, WUT and NREM in stage S1 was significantly higher than that in group B (P<0.05).The scores of visual space and executive function, attention, delayed memory, orientation and MOCA in group A were significantly lower than those in group B (P<0.05), but there was no significant difference in naming, language and abstract scores between group A and group B (P>0.05).Serum S-100beta level in group A was significantly lower than that in group B (P<0.05). In elderly patients with acute cerebral infarction with non-rapid eye movement sleep disorder, serum s-100 was negatively correlated with TST, SE, REMT, REM%, S2, S3+S4 (r=-0.466, -0.682, -0.612, -0.646, all P<0.05), positively correlated with SOL, WUT, and S1 (r=0.435, 0.587, 0.187, all P<0.05), and negatively correlated with the total score of MOCA (r=-0.327, P<0.05). Conclusion: Serum S-100beta is associated with sleep quality and cognitive function in elderly patients with acute cerebral infarction and non-REM sleep disorder.

Key words： Acute cerebral infarction Non-REM sleep disorder S-100beta Cognitive function Sleep quality

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.04.023 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I4/625

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