普罗布考对脑梗塞患者血液流变学及凝血相关指标的影响

doi:10.3969/j.issn.1006-6233.2020.04.020

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Abstract Objective: To study the effect of probucol on Hemorheology and coagulation in patients with cerebral infarction. Methods: 86 patients with cerebral infarction admitted to our hospital from December 2017 to December 2018 were included in the study. They were randomly divided into two groups, 43 in each group. The control group was given routine basic treatment, while the observation group was given probucol on the premise of basic treatment, which lasted for 4 weeks. The changes of plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, activated partial thromboplastin time, thrombin time and fibrinogen were compared before and after treatment. The changes of hypersensitive C-reactive protein and matrix metalloproteinase-9 before and after treatment were analyzed, and the adverse reactions during treatment were observed. Results: The total effective rate was 90.70% in the observation group and 74.42% in the control group (P<0.05). The plasma viscosity, whole blood high shear viscosity and whole blood low shear viscosity in the observation group were significantly lower than those before treatment and after treatment in the control group (P<0.05), and the difference of the above indexes before and after treatment was significantly lower than that in the control group (P < 0.05). After treatment, the activated partial thromboplastin time and thrombin time in the observation group were significantly higher than those before treatment and after treatment in the control group (P < 0.05), and the difference of the above indexes before and after treatment was significantly higher than that in the control group (P<0.05); after treatment, the fibrinogen in the observation group was significantly lower than that before and after treatment in the control group (P < 0.05), and the difference before and after treatment was significantly lower than that in the control group (P<0.05). After treatment, the levels of serum high-sensitivity C-reactive protein and matrix metalloproteinase-9 in the observation group were significantly lower than those before and after treatment in the control group (P<0.05), and the differences of the above indexes before and after treatment were significantly lower than those in the control group (P < 0.05). The incidence of adverse reactions was 11.63% in the observation group and 18.60% in the control group (P>0.05). Conclusion: Probucol is effective in the treatment of cerebral infarction. It can effectively reduce plasma viscosity, whole blood high shear viscosity, whole blood low shear viscosity, improve hemorheology and coagulation function, reduce inflammation after cerebral infarction, and has good safety.

Key words： Cerebral infarction Probucol Hemorheology Coagulation function Inflammatory response

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	ZHANG Xiaojie
	GUO Aihong
	LI Yanjun

Cite this article:

ZHANG Xiaojie,GUO Aihong,LI Yanjun. Effects of Probucol on Hemorheology and Coagulation Related Indexes in Patients with Cerebral Infarction[J]. HeBei Med, 2020, 26(4): 609-615.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.04.020 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I4/609

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