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| Effect of Mechanical Thrombectomy Combined with Catheter Thrombolysis on Coagulation Function, Recurrence and Amputation in Patients with Acute Lower Extremity Arterial Embolism |
| WU Ligang, ZENG Hanqiang |
| Dongguan People's Hospital, Guangdong Dongguan 523000, China |
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Abstract Objective: To analyze the effects of mechanical thrombectomy combined with catheter thrombolysis on coagulation function, recurrence and amputation in patients with acute lower extremity arterial embolism. Methods: 84 patients with acute lower extremity arterial embolism in our hospital from January 2016 to August 2018 were randomly divided into study group and control group, 42 cases in each group. The control group was treated with mechanical thrombectomy, and the study group was treated with catheter thrombolysis on this basis. After treatment, the clinical treatment and coagulation function [including prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), D-Dimer (D-D)] of the two groups were compared, and the amputation rate and recurrence rate of the two groups were compared. Results: After treatment, the total effective rate of the study group was significantly higher than that of the control group (P<0.05). The levels of FIB and D-D in the two groups were significantly lower than those before treatment, and PT and APT were significantly higher than those before treatment (P<0.05); the levels of FIB and D-D in the study group were significantly lower than those in the control group, and PT and APT were significantly higher than those in the control group (P<0.05). The recurrence rate of the study group was significantly lower than that of the control group (P<0.05), but there was no significant difference in amputation rate between the two groups (P>0.05). Conclusion: Mechanical thrombectomy combined with catheter thrombolysis can significantly improve the coagulation function of patients with acute lower extremity arterial embolism, better reduce the recurrence rate, lower the risk of amputation, clinical efficacy is clear.
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[1] 孙勇,余朝文,卢冉,等.经导管持续溶栓联合间歇性脉冲抗凝治疗急性下肢深静脉血栓的效果观察[J].蚌埠医学院学报,2018,43(8):1016~1018,1021.
[2] 景阳,丁萌,付久园,等.介入技术治疗下肢手术后深静脉血栓形成的效果与分析[J].河北医学,2019,25(6):1006~1010.
[3] 朴龙,李成福,朴雄,等.不同入路置管溶栓治疗下肢深静脉血栓的疗效比较[J].中国现代医学杂志,2018,28(21):84~87.
[4] 赵健,刘兆玉,马羽佳,等.大管径导管抽吸血栓治疗急性下肢动脉栓塞的疗效分析[J].医学影像学杂志,2017,27(8):1546~1549.
[5] 朱海瑾,楼伟华,楼晓红,等.高压氧治疗双下肢动脉栓塞取检术后早期肢体缺血再灌注损伤1例[J].中国基层医药,2016,23(24):3820~3821.
[6] Grip O, Wanhainen A, Acosta S, et al. Long-term outcome after thrombolysis for acute lower limb ischaemia[J]. Eur Vasc Endovasc Surg,2017,53(6):853~861.
[7] Huang G, Tang Y, Wang H, et al. Lower limb vein thrombosis-induced pulmonary embolism and paradoxical multiple arterial embolisms: a case report with a 10-year follow-up[J]. Medicine (Baltimore),2019,98(30):e16522.
[8] Bulvas M, Sommerova Z, Vanek I, et al. Prospective single-arm trial of endovascular mechanical debulking as initial therapy in patients with acute and subacute lower limb ischemia: One-year outcomes[J].Endovasc Ther,2019,26(3): 291~301.
[9] 张惠林,殷世武,项廷淼,等.Angiojet血栓抽吸系统联合置管溶栓在急性肢体动脉栓塞疾病中的应用[J].中华临床医师杂志(电子版),2018,12(3):185~188. |
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2020, Vol. 26 
