慢性肾病患者血尿酸与动脉钙化的相关性研究

doi:10.3969/j.issn.1006-6233.2020.04.015

Abstract
Figure/Table
References
Related Citation (6)

Download: PDF (2366 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To investigate the correlation between serum uric acid with coronary artery calcification in patients with chronic kidney disease (CKD). Methods: 142 patients with CKD hospitalized in Chongqing Three Gorges Central Hospital from April 2016 to January 2019 were selected as the research subjects. The arterial calcification was monitored by X-ray at admission. And Simultaneous determination of serum uric acid (UA), urea nitrogen (BUN), serum creatinine (SCr), serum calcium and other blood biochemical indicators. According to the results of coronary artery calcification, the patients were divided into calcification group (66 cases) and non-calcification group (76 cases), Arterial calcification scores and UA levels after hemodialysis were measured, the relationship between Arterial calcification scores with UA and the risk factors of coronary artery calcification were analyzed. Results: The TG, CRP, 24h urinary protein, proportion of hypertension and chronic nephritis history in calcification group were significantly higher than those in non-calcification group (P<0.05), while Hb and eGFR were lower than those in non-calcification group (P<0.05); the UA level before dialysis in calcification group was higher than that in non-calcification group (P<0.05), and the calcification scores and UA level after dialysis were lower than those before dialysis (P<0.05); there was a positive correlation between Arterial calcification scores with UA level in CKD patients (P<0.05); UA and eGFR were risk factors for coronary artery calcification in CKD patients. Conclusion: Serum uric acid can aggravate arterial calcification in patients with CKD. Early intervention of uric acid therapy and adequate dialysis may be an effective way to improve arterial calcification.

Key words： Chronic kidney disease Blood uric acid Coronary artery calcification

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHOU Long
	HU Chunlan
	WU Zecheng
	et al

Cite this article:

ZHOU Long,HU Chunlan,WU Zecheng, et al. Correlation between Serum Uric Acid with Artery Calcification in Patients with Chronic Kidney Disease[J]. HeBei Med, 2020, 26(4): 589-594.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.04.015 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I4/589

[1] Ventimiglia E, Larcher A, Trevisani F, et al. Post-operative complications increase the risk of long-term chronic kidney disease after nephron sparing surgery in renal cancer patients with normal preoperative renal function[J]. BJU Int, 2019, 124(3):457~461.
[2] Johnson RJ, Bakris GL, Borghi C, et al. Hyperuricemia, acute and chronic kidney disease, hypertension, and cardiovascular disease: report of a scientific workshop organized by the national kidney foundation[J]. Am Kidney Dis, 2018, 71(6):851~865.
[3] 蔡宏,张伟明,祝旭颖,等.血清可溶性Klotho水平与维持性血液透析患者预后的关系[J].中华肾脏病杂志,2017,33(5):334~341.
[4] Chen J, Budoff MJ, Reilly MP, et al. Coronary Artery Calcification and Risk of Cardiovascular Disease and Death Among Patients With Chronic Kidney Disease[J]. JAMA Cardiol, 2017, 2(6):635~643.
[5] 杨军,缪洪芸.维持性血液透析患者血尿酸与动脉钙化的相关性研究[J].国际检验医学杂志,2019,40(3):318~320.
[6] 上海慢性肾脏病早发现及规范化诊治与示范项目专家组.慢性肾脏病筛查诊断及防治指南[J].中国实用内科杂志,2017,37(1):28~34.
[7] Adragao T, Ferreira A, Frazao JM, et al. Higher mineralized bone volume is associated with a lower plain X-Ray vascular calcification score in hemodialysis patients[J]. PLoS One, 2017, 12(7):e0179868.
[8] Ulutas O, Taskapan MC, Dogan A, et al. Vascular calcification is not related to serum fetuin-A and osteopontin levels in hemodialysis patients[J]. Int Urol Nephrol, 2018, 50(1):137~142.
[9] 付金财,于波.冠状动脉钙化评分在冠心病风险分层及预测中的作用[J].心血管康复医学杂志,2018,27(5):603~606.
[10] El TB, Khamis OA, Elshehaby A, et al. Relationship between serum osteoprotegerin and vascular calcifications in hemodialysis patients[J]. Egypt Heart, 2017, 69(2):149~155.
[11] Esche J, Krupp D, Mensink GBM, et al. Dietary potential renal acid load Is positively associated with serum uric acid and odds of hyperuricemia in the german adult population[J].Nutrition, 2018, 148(1):49~55.
[12] 刘天元,何樟秀,郝丽荣.高尿酸血症与慢性肾脏病关系研究进展[J].中国血液净化,2018,17(6):416~419.
[13] Jun JE, Lee YB, Lee SE, et al. Elevated serum uric acid predicts the development of moderate coronary artery calcification independent of conventional cardiovascular risk factors[J]. Atherosclerosis, 2018, 272(1):233~239.
[14] Sherman L, Pelter MA, Deamer RL, et al. Association between encounter frequency and time to blood pressure control among patients with newly diagnosed hypertension: a retrospective cohort study[J].Clin Hypertens, 2018, 20(3):429~437.
[15] 易扬,路建饶,吴好,等.慢性肾脏病患者冠状动脉钙化影响因素分析[J].第二军医大学学报,2018,39(6):621~626.