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| APOE Gene Expression in Elderly Patients with AD at Different Age Stages and its Relationship with Cognitive Impairment |
| ZHU Ye, CHEN Yan, PENG Le, et al |
| Jiangxi Provincial People's Hospital, Jiangxi Nanchang 330000, China |
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Abstract Objective: To investigate the expression of apolipoprotein E (APOE) gene in elderly patients with Alzheimer's disease (AD) at different ages and stages, and to analyze the relationship between APOE gene expression and cognitive impairment. Methods: 64 elderly AD patients admitted to our hospital from June 2018 to June 2019 were selected as the main subjects. According to the age of onset, the patients were divided into early-onset AD group (<65 years old) and late-onset AD group (>65 years old). The late-onset AD group was further divided into old-onset group (65-80 years old), old-onset group (80~90 years old) and longevity Group (>90 years old), with 16 cases in each group. The APOE gene expression in peripheral blood of four groups was detected, and the correlation between APOE gene expression and cognitive impairment was analyzed by Pearson correlation. Results: E2/E2 APOE subtypes were not present in all 4 groups. In E3/E3 subtypes, the frequency of group 1 was the highest, 62.50% (10/16), followed by 43.75% of the 2 groups (7/16), in the E3/E4 subtype expression, the frequency of the three groups was the highest, 43.75% (7/16), followed by 37.50% (6/16) of the 4 groups, and the expression of the other subtypes was lower; APOE There are three E1/E3/E4 alleles, of which E3 has the highest frequency of expression, followed by E4, and E2 has the lowest frequency. The MMSE, ADAS-cog, and ADL scores of the 4 groups were statistically significant (P<0.05), and the MMSE scores were: 1 group>2 groups>3 groups>4 groups, and the ADAS-cog score:1 group<2 group<3 group<4 group, ADL score:1 group<2 group<3 group<4 group, the difference was statistically significant (P<0.05). The MMSE score, ADAS-cog score, and ADL score of patients with different APOE genotypes were statistically significant (P<0.05). There was no significant difference in LSD-t test between the two groups (P>0.05). Conclusion: The expression of APOE gene is different in AD patients with different ages, and the expression of APOE4 gene is closely related to cognitive dysfunction. Therefore, the age of AD can be delayed by regulating the expression of APOE4 gene.
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2020, Vol. 26 
