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| Effects of Remote Ischemia on Serum Cardiac Troponin and Systemic Inflammatory Response in Patients Undergoing Cardiac Valve Replacement |
| ZHUANG Huanwei, BAI Shutang, FU Hongdu, et al |
| Haikou Hospital Affiliated to Xiangya Medical College, Hainan Haikou 570208, China |
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Abstract Objective: To investigate the effects of remote ischemic treatment (RIPC) on serum cardiac troponin I (cTnI) and systemic inflammatory response in patients undergoing cardiac valve replacement. Methods: A total of 66 patients who underwent cardiac valve replacement in our hospital from August 2017 to August 2019 were selected as the study subjects. They were divided into study group and control group according to the random number table method, with 33 cases in each group. Patients in the study group were treated with RIPC after anesthesia induction, and patients in the control group were treated with conventional tourniquet. The effects of different treatments on CTnI and inflammatory factors (TNF-α,IL-6,IL-8) were compared between the two groups. Results: CTnI concentration in the two groups increased gradually with time after aortic dissection (P<0.05), and the concentration of cTnI in the study group was lower than that in the control group (P<0.05).At the same time, the BNP level of the patients in the two groups was gradually decreased (P<0.05) until 6h before anesthesia induction, and increased rapidly after 24h of aorta opening (P<0.05). However, the BNP level in the study group was lower than that in the control group (P<0.05) after 30min, 6h and 24h of aorta opening. In the other two groups.the levels of TNF-α,IL-6,IL-8 increased at one day after opereation (P<0.05), but the levels of TNF-α,IL-6,IL-8 at 3 and 7 days after operation were showed a dounwardtreat (P<0.05). and the level of TNF-α,IL-6,IL-8 in paeitns in this study group were louer than those inthe control group at 3 and 7 days after surgery (P<0.05).Conclusion: The treatment of distant ischemia can effectively reduce the myocardial ischemia-reperfusion injury, play a protective role in valve replacement surgery, and has a positive significance for the reduction of inflammatory response in patients.
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2020, Vol. 26 
