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| Effect of Oral Orthodontic Reconstruction Combined with Kangfuxin Liquid |in Treating Wrong Jaw Deformity and Its Effect on RANKL| and OPG in Gingival Crevicular Fluid |
| HU Fang, LUO Jun, TIAN Wei |
| The First People's Hospital in Jiangxia District of Wuhan, Hubei Wuhan 430200, China |
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Abstract Objective: To study the effect of oral orthodontic reconstruction combined with Kangfuxin liquid in the treatment of wrong jaw deformity and its effect on RANKL and OPG in gingival crevicular fluid. Methods: 78 patients with wrong jaw deformity were choosen in our hospital from August 2015 to July 2016, those patients were divided into observation group and control group according to the order of admission. The control group used oral orthodontic reconstruction, the observation group were given Kangfu new liquid on the basis of control group to complete the treatment. The clinical efficacy, toothache degree, gingival crevicular fluid RANKL, OPG levels and adverse reactions were compared between the two groups. Results: The total effective rate of the observation group was significantly higher than that of the control group [92.31% (36/39) vs 66.67% (26/39)] (P <0.05). The degree of toothache in the observation group was significantly better than that in the control group (P <0.05). The level of RANKL in the gingival crevicular fluid was significantly lower than that in the control group [(45.87 ± 4.12) ug / L VS(84.86 ± 8.32) ug / L] (P <0.05), and the OPG level was significantly higher than that in the control group [(275.32 ± 21.56 ) Ug / L VS(135.98 ± 11.43) ug / L] (P <0.05). There was no significant difference in the adverse reaction rate between the observation group and the control group [(23.08% (9/39) vs 28.21% (11/39)] (P >0.05). Conclusion: Oral orthodontic reconstruction combined with Kangfenxin solution can effectively reduce the concentration of RANKL in gingival crevicular fluid, increase the concentration of OPG, alleviate the pain of patients, and have good clinical curative effect.
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[1]曾婧,郑德华,王旭霞,等.错颌畸形对成人心理健康状况的影响[J].山东大学学报(医学版),2014,11(06):94~97.
[2] 段小燕,周建荣,林双兰等.口腔正畸专科助手胜任力评价模型构建的研究[J].重庆医学,2015,11(19):2623~2625.
[3] 杨刚岭,王岩莉,舒明芳等.口腔正畸治疗感染患者病原菌分布及耐药性分析[J].中华医院感染学杂志,2014,12(16):3953~3954,3957.
[4] 刘芳,赖碧娟,郭鑫等.口腔正畸治疗期间医院感染因素及预防措施[J].中华医院感染学杂志,2013,23(2):364~365.
[5] Forster CS, Jerardi KE, Herbst L,et al. Right Test, Wrong Patient: Biomarkers and Value[J].Hosp Pediatr, 2016 ,6(5):315~317.
[6] 尹音. 儿童口腔学[M].北京:人民军医出版社,1995.
[7] 郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002.
[8] 刘洪,牟雁东,于晓光等.口腔正畸治疗中微型种植体支抗的稳定和安全性[J].中国组织工程研究,2016,20(8):1159~1164.
[9] 张文玲,薛鹏,赵勇等.口腔正畸治疗对口腔中细菌微生态影响的临床分析[J].江苏医药,2014,40(9):1095~1096.
[10] 吴欣,季玉花,刘国元等.口腔正畸治疗期间医院感染的临床分析[J].中华医院感染学杂志,2014,(18):4596~4598.
[11] Zhao YJ, Wang SW, Liu Y,et al. A method for rapid extracting three-dimensional root model of vivo tooth from cone beam computed tomography data based on the anatomical characteristics of periodontal ligament[J].Beijing Da Xue Xue Bao, 2017,49(1):54~59.
[12] Jung SY, Park JH, Park HS,et al. Transport distraction osteogenesis combined with orthodontic treatment in a patient with unilateral temporomandibular joint ankylosis[J].Am Orthod Dentofacial Orthop, 2017, 151(2):372~383.
[13] 舒丹.口腔正畸改建术对患者血清β-EP、5-HT影响及康复新液对治疗后牙痛的疗效研究[J].辽宁中医杂志,2016,12(05):988~991.
[14] Nakamura M, Yanagita T, Matsumura T,et al. A case of severe mandibular retrognathism with bilateral condylar deformities treated with Le Fort I osteotomy and two advancement genioplasty procedures[J].Korean Orthod, 2016 ,46(6):395~408.
[15] Munakata M, Ono Y, Hayama R,et al.Relationship between Occlusal Discomfort Syndrome and Occlusal Threshold[J].Kokubyo Gakkai Zasshi, 2016,83(1):7~12. |
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2017, Vol. 23 
