子宫内膜息肉中miR-210和HIF-1α的表达及意义

doi:10.3969/j.issn.1006-6233.2020.04.006

Abstract
Figure/Table
References
Related Citation (1)

Download: PDF (1259 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To observe the expressions of microRNA-210 (miR-210) and hypoxia inducible factor-1α (HIF-1α) in endometrial polyps (EP) and their clinical significances. Methods: From June 2018 to May 2019, 62 patients with endometrial polyps diagnosed by hysteroscopy and resected in our hospital were selected as the study subjects, called polyps group, and 62 normal endometrial patients with infertility or uterine malformations who underwent hysteroscopy and excluded EP during the same period were selected as the control study, called normal endometrium group. The levels of prolactin (PRL), estradiol (E2), testosterone (T), follicle stimulating hormone (FSH) and progesterone (P) were measured by enzyme-linked immunosorbent assay (ELISA), the relative expression levels of miR-210, HIF-1α, estrogen receptor (ER), progesterone receptor (PR) and vascular endothelial growth factor (VEGF) were detected by real-time fluorescence quantitative analysis (qRT-PCR), Pearson method was used to analyze the correlation between the expression levels of miR-210, HIF-1α and ER, PR, VEGF, and the expression levels of miR-210 and HIF-1α in EP tissues. Results: There was no significant difference in serum PRL, E2, T, FSH and P levels between EP patients and normal endometrium (P>0.05). The expression levels of miR-210, HIF-1α, ER and VEGF in polyps were significantly higher than those in normal intima group (P<0.05), and the expression levels of PR were significantly lower than those in normal intima group (P<0.05). MiR-210 was positively correlated with the expression of VEGF (P<0.05), HIF-1α was positively correlated with the expressions of ER and VEGF (P<0.05), and negatively correlated with the expression of PR (P<0.05). The expression level of miR-210 was positively correlated with HIF-1α (P<0.05). Conclusions: The expression of mir-210 and HIF-1 α in endometrial polyps of EP patients was up-regulated, and there was a positive correlation between them.

Key words： Endometrial polyps MicroRNA-210 Hypoxia inducible factor-1α

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LING Ling
	XU Guiqin
	NI Na

Cite this article:

LING Ling,XU Guiqin,NI Na. Expression Relationship and Significance of miR-210 and HIF-1α in Endometrial Polyps[J]. HeBei Med, 2020, 26(4): 549-553.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.04.006 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I4/549

[1] 霍宇峰.两种疗法用于子宫内膜息肉术后治疗的临床观察[J].中国药物与临床,2018,18(7):1176~1177.
[2] 周冠伦,张宁,李菲.子宫内膜息肉发病机制及临床诊疗策略的相关研究进展[J].中国妇幼保健,2019,34(7):1681~1683.
[3] Dai Y, Lin X, Xu W, et al. MiR-210-3p protects endometriotic cells from oxidative stress-induced cell cycle arrest by targeting BARD1[J]. Pharmazie, 2019, 71(8):434~438.10(2):144~149.
[4] 朱媛媛,崔毓桂,冒韵东.HIF-1α在子宫内膜异位症中的研究进展[J].生殖医学杂志,2017,26(4):377~381.
[5] 覃丽渊,花艳蕉,覃超喜,等.子宫内膜息肉发病机制的研究进展[J].中国计划生育学杂志,2018,26(6):525~529.
[6] Bittencourt CA, Dos Santos Simes R, Bernardo WM, et al. Accuracy of saline contrast sonohysterography in detection of endometrial polyps and submucosal leiomyomas in women of reproductive age with abnormal uterine bleeding: systematic review and meta-analysis[J]. Ultrasound Obstet Gynecol, 2017, 50(1):32~39.
[7] 张冬梅,纪琼琼.宫腔镜下电切术与刮宫术治疗子宫内膜息肉的疗效比较[J].中国临床研究,2017,30(11):1536~1538.
[8] Lu G, Zhang J, Liu X, et al. Regulatory network of two circRNAs and an miRNA with their targeted genes under astilbin treatment in pulmonary fibrosis[J].Cell Mol Med, 2019, 23(10):6720~6729.
[9] Zhuo Z, Yu H. miR-205 inhibits cell growth by targeting AKT-mTOR signaling in progesterone-resistant endometrial cancer Ishikawa cells[J]. Oncotarget, 2017, 8(17):28042~28051.
[10] Pateisky P, Pils D, Szabo L, et al. Hsa-miRNA-154-5p expression in plasma of endometriosis patients is a potential diagnostic marker for the disease[J]. Reprod Biomed Online, 2018, 37(4):449~466.
[11] 梁朵献,邱华娟,纪燕琴.ER-α、PR、Ki-67和VEGF的异常表达与子宫内膜息肉形成及术后复发的关系[J].齐齐哈尔医学院学报,2017,38(1):1~3.
[12] Zhang F, Liu XL1, Wang W, et al. Expression of MMIF, HIF-1α and VEGF in serum and endometrial tissues of patients with endometriosis[J]. Curr Med Sci, 2018, 38(3):499~504.
[13] 王淑贞,王秋红.HIF-1α和VEGF在子宫内膜癌中的临床表达及相关性[J].实用癌症杂志,2017,32(4):536~538.
[14] Zhang L, Xiong W, Li N, et al. Estrogen stabilizes hypoxia-inducible factor 1α through G protein-coupled estrogen receptor 1 in eutopic endometrium of endometriosis[J]. Fertil Steril, 2017, 107(2):439~447.