持续感染状态的HPV-16及HPV-58亚型在宫颈病变中的分布及危险因素

doi:10.3969/j.issn.1006-6233.2020.04.004

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Abstract Objective:The distribution of HPV-16 and HPV-58 subtypes and the risk factors leading to cervical lesions were analyzed.Methods:From January 2017 to March 2019, 100 patients with cervical lesions were selected as observation group and 90 patients with normal physical examination as control group. The distribution of HPV-16 and HPV-58 subtypes of human papillomavirus (Human papillomavirus,HPV) subtypes in patients with persistent infection in the observation group was analyzed. According to the general data of the two groups, univariate and binary Logistic regression analysis was used to analyze the influencing factors and independent risk factors of cervical lesions in the observation group.Results:The highest proportion of cervical cancer patients was HPV-16 (73.68%), HPV-58 (78.95%), cervical intraepithelial neoplasia II-III (60.00%), HPV-58 (66.67%), cervical intraepithelial neoplasia I (36.84%), HPV-58 (31.58%), cervicitis (35.72%), HPV-58 (46.43%); the distribution of HPV-16 and HPV-58 in different types of cervical lesions was statistically significant (P<0.05). Single factor and binary logistic regression analysis showed that age of first sexual behavior, number of sexual partners, vaginitis and family history of cervical cancer were the influencing factors and independent risk factors of cervical lesions.Conclusion: The proportion of HPV-16 and HPV-58 in the patients with cervical intraepithelial neoplasia (HPV-16) and HPV-58 (HPV-58) in the patients with cervical intraepithelial neoplasia (HPV-16), followed by cervical intraepithelial neoplasia (II-III), I-phase, and at least cervicitis (Cervicitis). The age of initial sexual behavior, the number of sexual partners, the inflammation of the vagina, the family history of the cervical cancer are the independent risk factors that lead to the cervical lesion.

Key words： Persistent infection status Human papillomavirus Cervical lesions

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	LIU Qunxiang
	WANG Li
	LI Jiangli

Cite this article:

LIU Qunxiang,WANG Li,LI Jiangli. The Distribution and Risk Factors of HPV-16 and HPV-58 Subtypes in Cervical Lesions with Persistent Infection[J]. HeBei Med, 2020, 26(4): 541-545.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.04.004 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I4/541

[1] 李娟,刘月红,顾萍,等.宫颈液基细胞学检查联合人乳头瘤病毒基因分型检测对宫颈病变的筛查意义[J].实用临床医药杂志,2019,23(14):72~75.
[2] Niccolai L M, Meek J I, Brackney M, et al. Declines in HPV-associated high-grade cervical lesions after introduction of HPV vaccines in Connecticut, US, 2008-2015[J]. Clinical Infectious Diseases an Official Publication of the Infectious Diseases Society of America, 2017, 65(6):884~889.
[3] 宋妮娜,唐荣荣,刘佳佳,等.TLRs在宫颈HPV16持续性感染及宫颈病变中的作用研究[J].实用妇产科杂志,2017,33(2):132~136.
[4] Yan W. Cervical cancers manifest a high rate of infection by a high-risk human papilloma virus subtype but a very low rate of infection by a low-risk subtype in the guiyang district of china[J]. Journal of Cancer, 2017, 8(7):1263~1270.
[5] Zhao S, Zhao X, Hu S, et al. Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North China[J]. Chinese Journal of Cancer Research, 2019, 31(4):663~672.
[6] 童婷婷,马杰,董丽杰,王莉.宫颈鳞癌患者宫颈液基脱落细胞中P16、P53蛋白及HPVE6/E7 mRNA的表达[J].郑州大学学报(医学版),2017,52(5):637~640.
[7] Chatzistamatiou K, Moysiadis T, Vryzas D, et al. Cigarette smoking promotes infection of cervical cells by high-risk human papillomaviruses, but not subsequent E7 oncoprotein expression[J]. International Journal of Molecular Sciences, 2018, 19(2):422.
[8] 陈雪,王志荣,刘洪洋,等.一种可诱发高滴度的针对人乳头瘤病毒HPV16,HPV52,HPV58中和抗体反应的HPV16嵌合病毒样颗粒疫苗的研究[J].病毒学报,2018,34(04):505~514.
[9] 王霞.宫颈癌及癌前病变中的HPV-16整合人宿主基因组的发生情况及其在宫颈癌筛查中的应用[J].河北医学,2017,23(11):1768~1772.
[10] Woestenberg P J, King A J, Ma V D S, et al. No evidence for cross-protection of the HPV-16/18 vaccine against HPV-6/11 positivity in female STI clinic visitors[J]. Journal of Infection, 2017, 74(4):393.
[11] 裴蕴锋,经先振,周娟,等.医院就诊人群HPV感染的流行病学特征及其与宫颈癌/癌前病变的关系[J].华中科技大学学报(医学版),2018,47(3):101~105.
[12] Bakari F, Abdul M A, Ahmed S A. The prevalence and course of preinvasive cervical lesions during pregnancy in a northern nigerian teaching hospital[J]. Annals of African Medicine, 2017, 16(2):74~80.
[13] 赵庆庆,尹格平.TNF-α启动子5个位点的基因多态性与山东省汉族妇女宫颈癌遗传易感性的相关性[J].山东大学学报(医学版),2018,56(2):28~33.