|
|
|
| Study on the Efficacy and Side Effects of Alprostadil Injection in the Treatment of Acute Ischemic Cerebral Infarction |
| FENG Yuan, HAN Bo |
| Characteristic Medical Center of Rocket Force Military of Chinese People's Liberation Army, Beijing 100000, China |
|
|
|
|
Abstract Objective: To investigate the prognosis and effect of conventional therapy combined with alprostadil injection in the treatment of acute ischemic cerebral infarction. Methods: According to a simple random group, 100 patients with acute ischemic cerebral infarction admitted to our hospital from April 2017 to June 2018 were divided into 50 patients in the study group and the control group. The control group received conventional therapy or oral aspirin. Lyric tablets and atorvastatin calcium tablets, intravenous infusion of Shuxuetong injection, the study group was treated with alprostadil injection on the basis of the control group, comparing the two groups of patients before and after treatment Differences in neurological deficit scores (NIHSS), clinical outcomes, and related indicators. Results: After 1 week and 2 weeks of treatment, the ADL and NIHSS scores of the two groups were significantly improved compared with those before treatment (P<0.05). After 1 week and 2 weeks, the score of the study group improved better than the control group. <0.05). After 1 week and 2 weeks of treatment, CRP, IL-6 and fibrinogen were significantly improved in both groups (P<0.05). After 1 week and 2 weeks, the study group improved. Control group (P<0.05). After 2 weeks of treatment, the total effective rate of the study group was 94%, and that of the control group was 80%. The study group was significantly higher than the control group (P<0.05). The adverse reactions after treatment were counted. In the study group, 1 patient developed mild diarrhea, 3 rashes occurred, 1 patient developed nasal mucosal hemorrhage, and 2 patients had epistaxis in the control group. There were no significant differences in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The combination of alprostadil and conventional therapy in patients with acute ischemic cerebral infarction has a significant effect on improving clinical outcomes.
|
|
|
|
|
|
[1] 解建国,刘峰.阿加曲班联合阿替普酶静脉溶栓治疗急性脑梗死的疗效及脑血管储备功能的影响[J].河北医学,2018,24(10):1602~1606.
[2] 刘伟.氯吡格雷联合前列地尔治疗急性脑梗死的应用效果评价[J].中国现代药物应用,2019,13(3):90~91.
[3] 黄宁涛.前列地尔治疗急性脑梗死的预后分析[J].北方药学,2018,15(12):56~57.
[4] 高长玉,吴成翰,赵建国,等.中国脑梗死中西医结合诊治指南(2017)[J].中国中西医结合杂志,2018,38(2):136~144.
[5] 王营.依达拉奉对急性脑卒中患者NIHSS评分、ADL评分及生活质量的改善作用[J].中国现代药物应用,2018,12(1):71~73.
[6] 张川.银杏达莫注射液联合前列地尔在急性脑梗死急诊治疗中对患者血液流变学、血小板活性指标和神经功能的影响[J].川北医学院学报,2018,33(4):483~487.
[7] 衡卫卫,朱亮,李君.丹参川芎嗪联合前列地尔对急性脑梗死患者神经功能缺损的影响[J].中国药业,2018,27(14):47~50.
[8] 孟颖,谢康,郑重.氯吡格雷及前列地尔治疗急性脑梗死55例临床分析[J].河北北方学院学报(自然科学版),2018,34(6):19~21,24.
[9] 刘琦,杨志勇,陈雄辉.氯吡格雷联合前列地尔治疗急性脑梗死的有效性分析[J].江西医药,2018,53(1):64~66.
[10] 赵岳红.氯吡格雷联合前列地尔治疗急性脑梗死的临床疗效观察[J].中国现代药物应用,2016,10(12):116~117. |
|
|
|
2020, Vol. 26 
