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| Observation on Clinical Effect of Baixuanxiatare Tablet Combined with Adapalene Gel on Acne Vulgaris |
| LIU Yan, WANG Hao, ZHANG Xiaoru, et al |
| Hebei Children's Hospital, Hebei Shijiazhuang 050031, China |
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Abstract Objective: To observe the curative effect of Baixuanxiatare tablet combined with Adapalene Gel on acne vulgaris. Methods: 116 cases of patients with acne disseminata admitted to our hospital from January 2018 to April 2019 were selected and numbered according to the order of admission, 58 cases were randomly selected as the treatment group, and the other 58 cases were used as the control group. The control group was implemented Adapalene Gel treatment, the the treatment group was implemented Baixuan Xiatare Tablet treatment on the basis of control group. The clinical efficacy, TCM syndrome score, serum testosterone (T) and estradiol (E2) levels, sebum secretion status and incidence rate of adverse reactions were compared between the two groups. Results: After treatment, the total effective rate of the treatment group was higher than that of the control group, with statistical difference (94.83%vs70.69%, P < 0.05). Compared with before and after treatment, and the scores of TCM syndromes in the treatment group were lower than those in the control group (7.41±1.73vs13.62±1.95, P＜0.05). Compared with before, the serum T levels of the two groups decreased on average, and the treatment group were lower than the control group (562.81±174.26 vs 681.93±194.17, 72.52±21.48 vs 95.49±23.62, P＜0.05). The E2 levels were significantly higher than the before treatment (P < 0.05), the treatment group was higher than the control group (48.35±9.26 vs 43.64±6.01, 128.36±28.25 vs 113.94±26.61, P＜0.05). The sebum secretion rates of the two groups after treatment were significantly lower than those before treatment (P < 0.05), and the sebum secretion rate of the treatment group was lower than that of the control group (1.04±0.13 vs1.39±0.21, P＜0.05). There was no significant difference in the incidence of adverse reactions between the treatment group and the control group (15.52% vs 13.79%, P＞0.05). Conclusion: Baixuanxiatare Tablet combined with Adapalene Gel in the treatment of acne disseminata has clinical curative effect. It can significantly improved the levels of serum testosterone and estradiol, effectively inhibits sebum secretion, and has high safety.
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2020, Vol. 26 
