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| Effects of Liraglutide on Endothelial Function and Immune Function in Elderly Patients with Type 2 Diabetes Mellitus Complicated with Hyperlipidemia |
| CHANG Pan, ZHANG Xiaomeng, WANG Xihui, et al |
| The Second Affiliated Hospital of Xi'an Medical University, Shaanxi Xi'an 710038, China |
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Abstract Objective: To investigate the effects of liraglutide on endothelial function and immune function in elderly patients with type 2 diabetes mellitus complicated with hyperlipidemia. Methods: 86 elderly patients with diabetes mellitus complicated with hyperlipidemia were enrolled in the general practice department of the hospital from January 2018 to February 2019. They were randomly divided into the control group and the liraglutide group, with 43 cases in each group. The control group was treated with metformin treatment. The liraglutide group was given subcutaneous injection of liraglutide. The two groups were observed for 2 months. Blood glucose and blood lipids were measured before and after the study [blood sugar (FBG), postprandial 2 h blood glucose (2 h PG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), low density lipid) Protein (LDL-C), high-density lipoprotein (HDL-C) and body mass index (BMI), comparing endothelial function indicators [ET-1 and NO] and immune function [hypersensitive C-reactive protein (hs-CRP), IgM and IgG]. Results: After treatment with liraglutide group, FBG, 2 h PG, TC and TG were lower than those in the control group (P<0.05). After treatment with liraglutide group, HbA1c, LDL-C and HDL-C were compared with the control group. There was no significant difference between BMI and BMI (P>0.05). After treatment with liraglutide, ET-1 was significantly lower than that before treatment (P<0.01). There was no significant difference in NO after treatment with liraglutide group (P>0.05). After treatment with liraglutide group, ET The level of -1 was lower than that of the control group (P<0.05), and the level of NO was higher in the liraglutide group than in the control group (P<0.05). The hs-CRP was decreased after treatment with the liraglutide group compared with the control group, while the IgG was higher than the control group (P<0.05). Conclusion: The effect of lilalutide on the elderly type 2 diabetes mellitus with hyperlipidemia is more obvious. It can alleviate the damage of endothelial function, increase the immune function and reduce the inflammatory response.
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2020, Vol. 26 
