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| Analysis on Predictive Value of Peripheral Blood Cell Parameters on Different Airway Inflammation Phenotypes in Patients with Acute Exacerbation of Asthma |
| GU Lixian·Ma Hemuti, REN Lili, WANG Wenjuan |
| The Second Affiliated Hospital of Xinjiang Medical University, Xinjiang Urumqi 830063, China |
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Abstract Objective: To investigate the predictive value of peripheral blood cell parameters on airway inflammation phenotypes in patients with acute exacerbation of asthma. Methods: The clinical data of 104 patients with acute exacerbation of bronchial asthma from May 2017 to May 2019 were collected. All patients were detected by induced sputum to identify airway inflammation phenotypes, and the induced sputum cell parameters and peripheral blood parameters were compared among different inflammation phenotypes. Spearman correlation coefficient was used to analyze the correlation between the induced sputum cell parameters and peripheral blood parameters, and ROC curve was drawn to analyze the predictive value of peripheral blood cell parameters on airway inflammation phenotypes. Results: There were significant differences in the parameters of eosinophil (EOS) and neutrophil (NE) in induced sputum and peripheral blood among patients with different airway inflammation phenotypes (P<0.05). The EOS count and percentage in peripheral blood were strongly positively correlated with sputum EOS percentage (P<0.05). The peripheral blood NE count and percentage were weakly positively correlated with sputum NE percentage (P<0.05). The values of area under the ROC curve of peripheral blood EOS count and percentage were 0.931 and 0.801 respectively in the prediction of sputum EOS≧3%. The values of area under the ROC curve of peripheral blood NE count and percentage were 0.651 and 0.706 respectively in the prediction of sputum NE≧61%. Conclusion: Peripheral blood parameters of EOS and NE in patients with acute exacerbation of asthma have certain predictive value on airway inflammation phenotypes. The peripheral blood EOS has higher predictive value, and analysis of peripheral blood cell parameters or can be used as the simple and rapid way to judge the phenotypes of airway inflammation in clinical practice.
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2020, Vol. 26 
