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| Effect of Oseltamivir Capsule Combined with Jinye Baidu Granule on Influenza A (H1N1) |
| LUO Yuchuan, HU Ke, LU Li |
| People's Hospital of Wuhan University, Hubei Wuhan 430060, China |
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Abstract Objective: To investigate the efficacy and safety of oseltamivir capsules combined with Jinye Baidu granules in the treatment of influenza A (H1N1). Methods: 204 patients with influenza A (H1N1) were randomly divided into trial group (100 cases) and control group (104 cases). Patients in the control group were administered with oseltamivir phosphate capsules orally (75 mg each time, twice a day) ; the trial group received oseltamivir phosphate capsules combined with Jinye baidu Granules (10g each time, 3 times a day) for oral treatment. Both groups of patients were treated continuously for 5 days. Blood routine, C-reactive protein (CRP) and liver and kidney function were measured in 2 groups before and after treatment. The efficacy and adverse reactions of each group of patients were observed. Results: The therapeutic effect of the experimental group comparing with that of the control group, the normal temperature rate was 91% vs 79.8% on the third day, the clinical symptom relief rate was 61% vs 47%, 79% vs 61% on the third and fifth day, and the total cure rate was 40% vs 26%. These indexes in the experimental group were significantly better than those in the control group (P < 0.05) ; The total ineffectiveness of the experimental group was lower than that of the control group (3% vs 7.7%), and the overall effective rate was higher than that of the control group (97% vs 92.3%), but the difference was not statistically significant (P>0.05). There were no significant differences in the rate of temperature recovery (97% vs 94.2%), deterioration rate (2% vs 5.8%) and negative rate of nasal swab virus (99% vs 97.1%) between the two groups on the 5th day (P>0.05). The overall adverse reaction rate between the two groups was compared (24% vs 22.1%) and no significant difference was found (P>0.05). There were no significant differences in white blood cells (WBC), percentage of monocytes (M%), liver and kidney function between the two groups before and after treatment (P>0.05). No significant difference was observed in C-reactive protein (CRP) between the two groups before treatment, but CRP in the trial group was significantly lower than that in the control group after treatment[ (11.9±3.6) mg/L vs (14.2±4.3) mg/L] (P<0.05). Conclusion: The combination of oseltamivir capsule and Jinye baidu granule can improve the clinical symptoms of influenza A (H1N1) more effectively without increasing adverse reactions.
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2020, Vol. 26 
