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Effects of Wisconsin and Siruikang on Weight Gain Endocrine and Metabolism in Hospitalized Male Patients with Schizophrenia |
XIONG Qian, YU Jianying, YAN Kai, et al |
Mental Health Center, West China Hospital, Sichuan University, Sichuan Chengdu 610041, China |
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Abstract Objective: To analyze the effects of wisconsin and Siruikang treatment on weight gain, endocrine and metabolism in hospitalized male patients with schizophrenia. Methods: A total of 126 male schizophrenia patients who were treated in the hospital from Aug. 2016 to Aug. 2018 were enrolled in the study. They were randomly divided into wisconsin group and the Siruikang group, 63 cases in each group. The curative effect, changes in body mass, fasting plasma glucose (FPG), blood lipids [total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL) ], endocrine hormones [prolactin (PRL), testosterone, free triiodothyronine (FT3), free thyroxine (FT4) ] before and after treatment were compared between the two groups. The occurrence of adverse reactions during treatment in both groups was statistically analyzed. Results: There was no significant difference in the effective rate of treatment between the wisconsin group and the Siruikang group (87.30% vs 88.89%, P>0.05). There was no significant difference in BMI, FPG, TC, TG, HDL, LDL, testosterone, FT3 or FT4 level in Siruikang group before and after treatment (P>0.05). There was no significant difference in FPG, HDL, LDL, PRL, testosterone, FT3 or FT4 level in wisconsin group before and after treatment (P>0.05). After treatment, level of PRL in Siruikang group was higher than that before treatment and that in wisconsin group (P<0.05). After treatment, levels of BMI, TC and TG in wisconsin group were higher than those before treatment and those in Siruikang group (P<0.05). The incidence of adverse reactions in siruikang group was significantly higher than that in wisconsin group (61.90% vs 33.33%, P<0.05). Conclusion: The curative effect of wisconsin and Siruikang is comparable on male schizophrenia patients. However, the effects of Siruikang are less on vertebral reaction and endocrine, with lower effects on sexual function, which increases treatment compliance of male patients.
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