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| Relationship between Serum TNF-α IL-6 sIL-2R Levels and the Severity and Prognosis of Children with Adenoid Hypertrophy |
| XU Yaxiong, WANG Yuanming, YANG Gang, et al |
| Dongguan Maternal and Child Health Care Hospital / Dongguan Women's and Children's Hospital, Guangdong Dongguan 523000, China |
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Abstract Objective: To explore relationship between serum TNF-α, IL-6, sIL-2R levels and the severity and prognosis of children with adenoid hypertrophy. Methods: The related data of 100 children with adenoid hypertrophy who were admitted to the hospital between August 2016 and August 2018 were retrospectively analyzed. The severity of hypertrophy and rate of adenoid re-hyperplasia were analyzed. The levels of serum indexes were compared among children with different severities of hypertrophy and different prognosis. The correlation between the three serum indexes and hypertrophy, and their predictive value for adenoid re-hyperplasia were analyzed. Results: Of the 100 children, there were 36, 32 and 32 cases with grade I, grade II and grade III hypertrophy, respectively. The rate of adenoid re-hyperplasia was 15.00% (15/100). Among them, there respectively were 2 cases (2.00%), 6 cases (6.00%), and 7 cases (7.00%) with adenoid re-hyperplasia (χ2 = 4.063, P>0.05). The order of levels of TNF-α, IL-6 and sIL-2R in children with different severities of hypertrophy from low to high was as follows: grade I, grade II and grade III (P<0.05). TNF-α, IL-6 and sIL-2R were positively correlated with the severity of adenoid hypertrophy (P<0.05). During follow-up, levels of TNF-α, IL-6 and sIL-2R in children with hyperplasia were significantly higher than those without (P<0.05). ROC curve analysis showed that the AUC of combined diagnosis (0.896) was better than that of single diagnosis with TNF-α, IL-6 or sIL-2R (0.845, 0.814, 0.709). Conclusion: The levels of serum TNF-α, IL-6 and sIL-2R are closely related to the severity of adenoid hypertrophy in children. All of them can be applied to predict the prognosis of children but the combined prediction of the three is better.
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2020, Vol. 26 
