|
|
|
| Analysis on the Correlation between the Levels of TNF-alpha, IL-6 and IL-8 in Synovial Fluid and X-ray Classification and Joint Function in Patients with Traumatic Arthritis |
| WU Xu, YAO Mengwei, GUO Zhen |
| Yangpu District Central Hospital of Shanghai, Shanghai 200090, China |
|
|
|
|
Abstract Objective: To analyze the correlation between the levels of inflammatory factors in synovial fluid and X-ray classification and knee function in patients with traumatic arthritis. Methods: 85 patients with traumatic arthritis (case group) and 45 health examinees (control group) were selected from January 2017 to January 2019. The levels of interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) in the synovial fluid of the two groups were compared. The differences of IL-6, IL-8 and TNF-α level in synovial fluid of patients with different X-ray grades were compared. Pearson correlation was used to analyze the relationship between KSS, HSS and IL-6, IL-8 and TNF-α level in synovial fluid. Results: The levels of IL-6, IL-8 and TNF-alpha in the synovial fluid of the case group were significantly higher than those of the control group (P<0.01). X-ray examination showed that there were 35 cases of grade I, 21 cases of grade II, 19 cases of grade III and 10 cases of grade IV. The levels of IL-6, IL-8 and TNF-α in synovial fluid of patients with different X-ray grading were significantly different (P<0.01), suggesting that the levels of IL-6, IL-8 and TNF-α in synovial fluid would increase with the increase of X-ray grading and the aggravation of bone injury. The average KSS score and HSS score were (63.47±10.46) and (67.98±13.28) respectively. Pearson correlation analysis showed that KSS score and HSS score at admission were negatively correlated with IL-6, IL-8 and TNF-α in synovial fluid (P<0.01), but not with ages and body mass index (P>0.05). Conclusion: The levels of inflammatory factors (IL-6, IL-8, TNF-α) in synovial fluid are closely related to X-ray classification and knee function in patients with traumatic arthritis. With the increase of X-ray classification, knee function is significantly weakened, and the levels of inflammatory factors (IL-6, IL-8, TNF-α) in synovial fluid are significantly increased.
|
|
|
|
|
|
[1] Ge JJ, Lu WK, Zhu N, et al.Effect of LGR4 on synovial cells and inflammatory factors in rats with traumatic osteoarthritis[J].Eur Rev Med Pharmacol Sci,2019,23(16):6783~6790.
[2] Fairweather J, Jawad AS. Post-traumatic chronic seronegative monarthritis responding to antitumor necrosis factor-alpha therapy[J].Saudi Med,2018,39(5):526~527.
[3] Guan YJ, Li J, Yang X, et al.Evidence that miR-146a attenuates aging- and trauma-induced osteoarthritis by inhibiting Notch1, IL-6, and IL-1 mediated catabolism[J].Aging Cell,2018,17(3):e12752.
[4] Hughes AP, Salzmann SN, Aguwa OK, et al. HSS dysphagia and dysphonia inventory (HSS-DDI) following anterior cervical fusion: Patient-derived, validated, condition-specific patient-reported outcome measure outperforms existing indices[J].Bone Joint Surg Am,2018,100(10):e66.
[5] 李广恒,戴尅戎.膝关节骨性关节炎分子发病机制和治疗展望[J].郑州大学学报(医学版),2015,59(2):149~152.
[6] 张新玉.骨关节炎发病机理的研究进展[J].河北医学,2016,22(4):666~668.
[7] Panina SB, Krolevets IV, Milyutina NP, et al. Circulating levels of proinflammatory mediators as potential biomarkers of post-traumatic knee osteoarthritis development[J].Orthop Traumatol,2017,18(4):349~357.
[8] Burkhart KJ, Hollinger B.Post-traumatic arthritis in the young patient : Treatment options before the endoprosthesis[J].Orthopade,2016,45(10):832~843.
[9] Grodzinsky AJ, Wang Y, Kakar S, et al. Intra-articular dexamethasone to inhibit the development of post-traumatic osteoarthritis[J].Orthop Res,2017,35(3): 406~411.
[10] 黄勤,毛慧慧.miR-146干预PI3K/Akt信号通路对类风湿关节炎滑膜成纤维细胞的影响[J].河北医科大学学报,2019,40(6):650~653,657. |
|
|
|
2020, Vol. 26 
