黄芪颗粒对病毒性心肌炎患儿炎症因子水平及细胞免疫的影响

doi:10.3969/j.issn.1006-6233.2020.02.003

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Abstract Objective: To investigate the effect of Astragalus membranaceus on inflammatory factors and cellular immunity of viral myocarditis patients. Methods: 70 children with viral myocarditis hospitalized in our hospital from April 2016 to March 2018 were selected as the study subjects. According to the random number table method, they were divided into study group (38 cases) and control group (32 cases).The control group received conventional treatment, while the study group continued to use astragalus on the basis of the former.The clinical efficacy, inflammatory factors (TNF-alpha, il-6, il-17) and cellular immunity of the two groups were compared before and after treatment.To evaluate the clinical value of astragalus in children with viral myocarditis. Results: The total effective rate in the study group (89.47%) was greater than that in the control group (68.75%) (χ² =4.663, P<0.05). Repeated measurement analysis of variance showed that the time point, group, time point and interaction effect of CK, CK-MB, LD, cTnI, TNF - α, IL-6, IL-17, CD3 +, CD4 +, CD4 + / CD8 + levels in the two groups were statistically significant (P<0.05), and the levels of CK, CK-MB, LD, cTnI, TNF - α, IL-6, IL-17 in the study group were lower than those in the control group at 1 or 2 weeks after treatment. The levels of CD3 +, CD4 +, CD4 + / CD8 + were significantly higher than those of the control group (P<0.05). Conclusion: Astragalus membranaceus has a significant effect on children with viral myocarditis. It can effectively improve the immune function of children, reduce the incidence of inflammation, and has a positive significance for the recovery of children after treatment.

Key words： Viral myocarditis Astragalus membranaceus Inflammatory cytokines Cellular immunity

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.02.003 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I2/185

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