黄芪对病毒性心肌炎患儿相关细胞因子及HSP70的影响

doi:10.3969/j.issn.1006-6233.2020.01.037

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Abstract Objective: To observe the effect of Astragalus membranaceus on cytokines and HSP70 in children with viral myocarditis (VMC). Methods: 70 children with viral myocarditis clinically confirmed in our hospital from April 2016 to March 2018 were selected as research objects, randomly divided into 38 cases in the research group and 32 cases in the control group. The control group used conventional treatment, observation group in the conventional treatment on the basis of oral huangqi granules. Venous blood of the children was extracted one week later, and the following indicators, il-1, il-6, ifn-gamma, tnf-alpha and HSP70, were detected respectively. Results: 1. Il-1, il-6, ifn-gamma and tnf-alpha of the children in the study group and the control group were significantly decreased after treatment compared with those before treatment (P<0.05), with statistically significant differences. Il-1, il-6, ifn-gamma and tnf-alpha of the children in the study group decreased significantly after treatment compared with that of the control group (P<0.05), with statistically significant differences. 2. HSP70 level of children in the study group and control group increased significantly after treatment compared with that before treatment; The level of HSP70 in the study group was significantly different from that in the control group (P<0.05). Conclusion: Astragalus can reduce the concentration of il-1, il-6, ifn-gamma and tnf-alpha in children with viral myocarditis, and up-regulate the level of HSP70.

Key words： Pediatric viral myocarditis Astragalus Cytokine HSP70

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2020.01.037 OR http://www.hbyxzzs.cn/EN/Y2020/V26/I1/154

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