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| Effects of Metformin Combined with Ethinyl Estradiol Cyproterone on Polycystic Ovary Syndrome |
| HOU Jing, ZHANG Yi, GUO Yanwei, et al |
| Affiliated Hospital of Chengde Medical College, Hebei Chengde 067000, China |
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Abstract Objective: To investigate the effect of Metformin combined with Ethinyl Estradiol Cyproterone in the treatment of polycystic ovary syndrome (PCOS). Methods: 90 PCOS cases in our hospital from January 2017 to January 2018 were randomly divided into control group (oral Ethinylestradiol Cycloprogesterone) and observation group (oral Ethinylestradiol Cycloprogesterone + Metformin) by the random number table with simple randomization method, 45 cases in each group, corresponding treatment was given. The clinical data of the two groups were recorded .Serum galactose lectin - 3 (Galectin - 3) level, sex hormones, blood lipid, fasting blood sugar, insulin levels and other indicators of the patients were measured before and after treatment. Results: Before treatment, there was no significant difference between the observation group and the control group (P>0.05). After treatment, the difference before and after treatmentthe of body mass index (BMI), waist-to-hip ratio (WHR), Galectin-3 level, luteinizing hormone (LH), testosterone (T), estradiol (E2), triglyceride (TG), high-density lipoprotein (HDL),low-density lipoprotein (LDL) and fasting serum glucose (FPG), fasting insulin (FINS), homeostasis model assessment-insulin resistance index (HOMA-IR) and ovulation rate and pregnancy rate were significantly higher than those of the control group, abortion rate was significantly lower than those of the control group, and the difference were statistically significant (P<0.05). There were no significant differences in the difference between follicle stimulating hormone (FSH) and total cholesterol (TC) in the observation group and the control group (P>0.05). Conclusion: Metformin combined with Ethinyl Estradiol Cyproterone has a good therapeutic effect on PCOS,which can effectively regulate sex hormone levels and alleviate insulin resistance.
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2020, Vol. 26 
