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Efficacy of CRRT on Severe Pancreatitis and Its Influence on Pancreatic Microcirculation Indexes and Serum Ghrelin and PCT Levels |
LIU Yan, CHEN Qin, YUAN Xue, et al |
The Second Clinical Medical College of North Sichuan Medical College, Nanchong Central Hospital, Sichuan Nanchong 637000, China |
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Abstract Objective: To analyze the efficacy of continuous renal replacement therapy (CRRT) in the treatment of severe pancreatitis and its influence on pancreatic microcirculation indexes and serum Ghrelin and procalcitonin (PCT) levels. Methods: The clinical data of each 102 patients with severe pancreatitis treated by CRRT (observation group) and conventional treatment (control group) were retrospectively analyzed. The times of clinical indexes remission were recorded in the two groups, and pancreatic microcirculation indexes [pancreatic blood flow (BF), blood flow volume (BV)], serological markers [Ghrelin, PCT, thromboxane A2 (TXA2)] and acute physiology and chronic health evaluation (APACHE II), and Balthazar computed tomography (CT) severity index (CTSI) were compared between the two groups before treatment and after 3d of treatment. Results: The recovery time of serum amylase, bowel sounds, abdominal pain remission and abdominal distension remission in observation group were lower than those in control group (P<0.05). After 3d of treatment, the pancreatic microcirculation indexes (pancreatic BF, BV) in the two groups were increased compared with those before treatment (P<0.05), and the indexes in observation group were higher than those in control group (P<0.05). Serological markers (serum Ghrelin, The PCT, TXA2) and scores of APACHE II and CTSI in the two groups were decreased compared with those before treatment (P<0.05), and the markers and scores in observation group were lower than those in control group (P<0.05). Conclusions: CRRT therapy has significant effects in the treatment of severe pancreatitis. And it can not only promote the relief of symptoms, but also relieve the pancreatic microcirculation disorder, and it has positive significance in disease outcomes of patients.
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[1] 徐小彭,李敏雄,黄永鹏,等.乌司他丁治疗老年急性重症胰腺炎的临床研究[J].中国临床药理学杂志,2017,33(21):2110~2113. [2] 周瑜,王卫星.急性胰腺炎中微循环障碍相关研究进展[J].中华全科医学,2017,15(9):1559~1562. [3] 连凌云,李前进,杨和平,等.硝酸甘油联合区域性动脉持续灌注治疗重症胰腺炎效果及对微循环障碍改善观察[J].陕西医学杂志,2018,47(1):53~55. [4] 中华医学会外科学分会胰腺外科学组.重症急性胰腺炎诊治指南[J].中华外科杂志,2007,45(11):727~729. [5] 李华志,朱润.内镜术联合腹腔镜灌洗治疗急性重症胰腺炎的临床研究[J].河北医学,2018,24(3):452~455. [6] 李冬英,方岚,魏际穷,等.不同浓度肝素液在重症胰腺炎患者连续肾脏替代疗法中心静脉导管封管中的应用[J].广东医学,2017,38(23):3666~3668. [7] 钟璇,肖先华.连续性肾脏替代疗法对重症胰腺炎患者肝肾功能的保护作用研究[J].解放军医药杂志,2017,29(4):99~102. [8] 符宜龙,舒艾娅,罗艳,等.限制性液体复苏联合连续性肾脏替代治疗在重症急性胰腺炎并发腹腔间隔室综合征治疗中的应用价值[J].中华消化外科杂志,2017,16(10):1042~1047. |
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