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| Effect of Laparoscopic Cadical Gastrectomy for Distal Gastric Cancer of Billroth ⅡAnastomosis Combined with Braun Anastomosis on Intestinal Barrier Function and Serum Inflammatory Factors Levels in Gastric Cancer |
| TIAN Qinglin, LI Yang, CHEN Xiaofeng |
| Shenyang Thoracic Hospital, Liaoning Shenyang 110044, China |
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Abstract Objective: To explore the effect of laparoscopic radical gastrectomy for distal gastric cancer of Billroth Ⅱanastomosis combined with Braun anastomosis on intestinal barrier function and serum inflammatory factors levels in gastric cancer. Methods: A retrospective analysis was performed on clinical data of each 56 patients who underwent laparoscopic radical gastrectomy for distal gastric cancer of Billroth Ⅱanastomosis (control group) and BillrothⅡanastomosis combined with Braun anastomosis (observation group) in our hospital. Perioperative indicators (operative time, gastrointestinal reconstruction time, intraoperative blood loss, postoperative exhaust time, postoperative hospital stay) and occurrence of postoperative complications were recorded in the two groups, and the intestinal barrier function [diamine oxidase (DAO), D-lactic acid], inflammatory factors [interleukin-6 (IL-6), interleukin-10 (IL-10)] and immune function [complements C3 , C4] were compared between the two groups before operation and at third day after operation. Results: There were no significant differences in the operative time, gastrointestinal reconstruction time, intraoperative blood loss, postoperative exhaust time and postoperative hospital stay between the two groups (P>0.05). The total incidence rate of postoperative complications in observation group was significantly lower than that in control group (P<0.05). At 3d after operation, the intestinal barrier function (serum DAO, D-lactic acid) and inflammatory factors (serum IL-6, IL-10) in the two groups were higher than those before operation (P<0.05), and the indexes in control group were higher than those in observation group (P<0.05). The immune function indexes (serum complements C3, C4) in the two groups were lower than those before operation (P<0.05), and the indexes in control group were lower than those in observation group (P<0.05). Conclusion: Billroth Ⅱanastomosis combined with Braun anastomosis has significant effects in laparoscopic radical gastrectomy for distal gastric cancer. And it can improve the postoperative intestinal barrier function and inflammatory level, and reduce the impact of surgery on immune function so as to help reduce postoperative complications.
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2020, Vol. 26 
