灵芝多糖对多柔比星诱导心肌细胞损伤保护作用的研究

doi:10.3969/j.issn.1006-6233.2017.10.002

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Abstract Objective: To study the protective effects of Ganoderma lucidum polysaccharides on adriamycin induced myocardial injury, and to explore the mechanism of adriamycin induced myocardial cell.Methods: Different concentrations of doxorubicin (1, 2, 4, 6μmol/L) with H9C2 were cultured for 6, 12, 24h,then calculated the cell inhibitory rates at different time and concentration;H₉C₂ cardiac myocytes were cultured with Ganoderma lucidum polysaccharides of different mass concentrations (0, 3.125, 6.25, 12.5, 25mg/L),adding doxorubicin after 1h,observing morphological changes of the cells after 24h,calculating the cell inhibition rate;MCF-7,KB,K562 were cultured with Ganoderma lucidum polysaccharides,adding doxorubicin after 1h,after 48h calculating the cell inhibition rate Results: The inhibition rate of 24h was the highest when 2μmol/L was cocultured with cells,25mg/L Ganoderma lucidum polysaccharides can significantly reduce the death of myocardial cells induced doxorubicin, and not reduce the anti-tumor effect of drugs. Conclusion: GL-PS has a protective effect on myocardial cells, had no effect on adriamycin inhibit the growth of tumor cells, there is no synergistic effect.

Key words： Ganoderma lucidum polysaccharide Myocardial cells Adriamycin

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2017.10.002 OR http://www.hbyxzzs.cn/EN/Y2017/V23/I10/1588