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| Study on the Correlation between Serum Calcium and Renin-angiotensin-aldosterone System in Patients with Diabetic Nephropathy |
| WU Yanqin, WENG Xiquan, CHEN Yanbo, et al |
| Puning People’s Hospital, Guangdong Jieyang 515300, China |
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Abstract Objective: To explore the correlation between serum calcium and index of in vivo renin-angiotensin-aldosterone system (RAAS) in patients with diabetic nephropathy (DN). Methods: 60 patients with type 2 diabetes mellitus (T2DM) admitted between January 2013 and July 2014 were selected for the study. According to the proteinuria level, the patients were divided into observation group 1 (normal proteinuria, n=18), observation group 2 (micro-proteinuria, n=20) and observation group 3 (large proteinuria, n=22), and another 30 healthy people at the same time period for physical examination were selected as control group. The levels of RAAS indexes [serum renin (PRA), angiotensin II (Ang II), aldosterone (ALD)] and serum calcium were compared in each group. The relationship between serum calcium and proteinuria was analyzed by Spearman correlation analysis. Pearman correlation analysis was used to analyze the relationship between PRA, AngII and ALD and serum calcium in DM patients. Results: The levels of PRA, AngII and ALD in observation groups 1, 2 and 3 were higher than those in control group (P<0.05), and the levels of PRA, AngII and ALD in observation group 1 were lower than those in observation groups 2 and 3 (P<0.05), and the levels of PRA, AngII and ALD in observation group 2 were lower than those in observation group 3 (P<0.05). The serum calcium level in observation group 1 was higher than that in observation groups 2 and 3 and control group (P<0.05), and the serum calcium level in observation groups 2 and 3 was lower than that in control group (P<0.05), and the serum calcium level in observation group 2 was lower than that in observation group 3 (P<0.05). Spearman correlation analysis showed that the serum calcium level was negatively correlated with urine protein degree of T2DM patients (P<0.05). Pearson correlation analysis showed serum calcium was negatively correlated with PRA, AngII and ALD (P<0.05). Conclusion: Serum calcium in DN patients is closely related to RAAS system. Monitoring serum calcium level is beneficial for diagnosis and treatment.
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2019, Vol. 25 
