GATA6和BMP2在口腔鳞癌中的表达关系及临床意义

doi:10.3969/j.issn.1006-6233.2019.11.030

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Abstract Objective: To detect the expressions of GATA6 and bone morphogenetic protein (BMP2) in oral squamous cell carcinoma (OSCC) tissues, analyze their relationship and explore their clinical significance. Methods: From April 2014 to December 2016, paraffin specimens from 56 patients with oral squamous cell carcinoma confirmed by pathology in our hospital were collected as observation group, and oral mucosa tissues from 42 normal persons were taken as control group. The expressions of GATA6 and BMP2 in oral tissues were detected by immunohistochemistry, and the relationship between GATA6 and BMP2 expression and clinicopathological characteristics of oral squamous cell carcinoma was analyzed. All patients were followed up and the prognostic effects of GATA6 and BMP2 expression on oral squamous cell carcinoma were analyzed. Results: The positive expression rates of GATA6 and BMP2 in oral squamous cell carcinoma tissues were significantly higher than those in normal tissues (P < 0.05); the expressions of GATA6 and BMP2 were correlated with TNM stage and tumor differentiation in OSCC patients (P < 0.05), but not with lymph node metastasis and tumor size (P > 0.05); the 2-year survival rate of patients with high expressions of GATA6 and BMP2 in oral squamous cell carcinoma were significantly lower than those in patients with low expression (P < 0.05); Cox model multivariate analysis showed that TNM stage, tumor differentiation, GATA6 and BMP2 expression were independent risk factors affecting the prognosis of patients. Conclusion: The expressions of GATA6 and BMP2 in oral squamous cell carcinoma are up-regulated, which is related to clinical stage, tumor differentiation and 2-year survival, it may be used as a biomarker for judging prognosis of patients.

Key words： Oral squamous Cell carcinoma GATA6 Bone morphogenetic protein

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.11.030 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I11/1872

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