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| Effect of Preconditioning with Rosuvastatin on Myocardial Reperfusion Left Ventricular Remodeling and Myocardial Injury after PCI for Acute Myocardial Infarction |
| LI Yinjun, XING Yu, XING Yunyun, et al |
| Shenyang Fourth People’s Hospital, Liaoning Shenyang 110031, China |
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Abstract Objective: To investigate the effect of different preconditioning with rosuvastatin on myocardial reperfusion, left ventricular remodeling and serum creatine kinase isoenzyme (CK-MB) and troponin T (cTnT) levels after percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). Methods: 150 patients with AMI were randomly divided into the observation group and the control group. The observation group was treated with oral rosuvastatin of 20 mg/d before operation and at 14 days after operation, and the dose was adjusted to 10 mg/d 14 days later. The control group was treated with oral rosuvastatin of 10mg/d before and after PCI. The intervention lasted for 1 month after operation. The thrombolysis in myocardial infarction (TIMI) grading in each group was observed at 1 week after operation. Left ventricular remodeling parameters [high-sensitivity C-reactive protein (hs-CRP), matrix metalloproteinase-9 (MMP-9)], serum CK-MB and cTnT levels were determined before and after operation. The major adverse cardiac events and adverse drug reactions in both groups during treatment were statistically analyzed. Results:The proportion of TIMI grade 3 in the observation group at 1 week after operation was significantly higher than that in the control group (93.33% vs 80.00%) (P<0.05). The levels of hs-CRP and MMP-9 in both groups increased significantly at 1 week after operation but the levels at 1 month after operation were significantly lower than those at 1 week after operation (P<0.05). The levels of serum CK-MB and cTnT in both groups decreased significantly at 1 week after operation, and the levels at 1 month after operation were significantly lower than those at 1 week after operation (P<0.05). The levels of hs-CRP, MMP-9, CK-MB and cTnT were significantly lower in the observation groupthan in the control group at 1 week and 1 month after operation (P<0.05). The incidence of severe arrhythmia in the observation group was significantly lower than that in the control group (P<0.05), but there was no significant difference in adverse drug reactions between the two groups (P>0.05). Conclusion:Compared with conventional dose, high-dose rosuvastatin can better improve myocardial reperfusion in patients with AMI after PCI, inhibit left ventricular remodeling, relieve myocardial injury, and reduce the incidence of severe arrhythmia, without increasing adverse drug reactions.
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2019, Vol. 25 
