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| Application of Bone Marrow Cytology and Peripheral Blood Routine Examination in the Diagnosis of Aplastic Anemia |
| ZHANG Quan, QU Yilin, YANG Kai |
| Integrated Traditional Chinese and Western Medicine Hospital, Hubei Wuhan 430015, China |
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Abstract Objective: To study the application value of bone marrow cytology combined with peripheral blood routine examination in the diagnosis of hypo-myelodysplastic syndrome (Hypo-MDS) and aplastic anemia (AA). Methods: The laboratory data of 20 patients with Hypo-MDS and 26 patients with AA admitted to our hospital from January 2014 to December 2018 were retrospectively analyzed. The results of bone marrow cytology and peripheral blood routine examination were compared between the two groups, and the application value of the two methods in identifying the two diseases was evaluated. Results: The results of peripheral blood test showed that the levels of platelet (PLT), reticulocyte (Ret), erythrocyte volume distribution width (RDW) and mean corpuscular volume (MCV) in AA group were significantly lower than those in Hypo-MDS group (P < 0.05). The morphological examination of peripheral blood microcells showed that the proportion of abnormal mature red blood cells in Hypo-MDS patients was significantly lower than that in Hypo-MDS group (P < 0.05). The frequencies of erythropoiesis, megakaryocyte hematopoiesis and trilineage hematopoiesis in Hypo-MDS patients were significantly higher than those in AA patients (P < 0.05). There was no significant difference in the frequencies of granulocyte hematopoiesis between the two groups (P > 0.05). Conclusions: It is difficult to distinguish Hypo-MDS from AA by a single laboratory examination, and a reasonable combination of bone marrow cytology and peripheral blood routine examination results can provide some reference for the identification of the two diseases, but for those who can not be identified, chromosome examination should be recommended for patients.
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2019, Vol. 25 
