横向骨搬移技术联合PRP对糖尿病足溃疡患者修复效果及生活质量的影响

doi:10.3969/j.issn.1006-6233.2019.10.038

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Abstract Objective: To investigate the effect of transverse bone transfer technique combined with PRP on repairing effect and quality of life in patients with diabetic foot ulcer . Methods: 134 patients with diabetic foot from January 2018 to October 2018 were chosen and divided into observation group and control group , 67 cases in each group . The control group was treated with PRP topical wound after debridement , the observation group was treated with PRP external wound combined with transverse tibial bone transport . Compare the expression changes of PDGFR , wound reduction rate , bacterial clearance rate , granulation tissue coverage , granulation tissue thickness and quality of life between the two groups . Results: Before the treatment , there was no significant difference in PDGFR-α and PDGFR-β between the two groups ( P＞0.05 ) . After treatment , the levels of PDGFR-α and PDGFR-β in both groups were higher than before treatment , and the observation group increased more significantly than the control group , P＜0.01 . The rate of wound reduction in the observation group was significantly higher than that in the control group , the rate of bacterial clearance and the coverage rate of granulation tissue were significantly higher than that in the control group , and the growth thickness of granulation tissue was significantly thicker than that in the control group , P all ＜0.01 . After treatment , the scores of treatment influence , psychological or spiritual , physiological function , and social relationship of the two groups were reduced , and the reduction of the observation group was greater than that of the control group , P＜0.01 . Conclusion: Transverse-bone transfer technique combined with PRP in the treatment of DFU can effectively improve the expression of PDGFR , improve the repair effect of ulcer wounds , and improve the quality of life.

Key words： Diabetes foot ulcer Transverse bone transfer technique Platelet-rich plasma Repairing effect Quality of life

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.10.038 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I10/1734

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