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| Effects of Type 2 Diabetes Mellitus on Blood Fat, Cardiac Function and Cardiovascular Disease with Hypothyroidism |
| REN Xiaoli, LIU Juan, YANG Jiao |
| Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Sichuan Chengdu 610000, China |
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Abstract Objective: To explore the effects of type 2 diabetes mellitus (T2DM) on cardiovascular-related complications in patients with subclinical hypothyroidism (SCH). Methods: 344 patients with SCH who were diagnosed in our hospital from April 2015 to April 2018 were retrospectively analyzed and were divided into T2DM-SCH group (64 cases) and SCH group (280 cases) according to whether patients were complicated by T2DM. The general data of age, gender and body mass index (BMI) were retrospectively analyzed, and the FPG, OGTT 2h blood glucose (2hPG), glycosylated hemoglobin (HbA1c) concentration, total cholesterol (TC), triglyceride (TG), low-density Lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), left ventricular systolic function (LVEF) and diastolic function (E/A) were detected, The complications of cardiovascular diseases were recorded in the two groups. Results: Compared with SCH group, the levels of serum FPG, 2hPG, HbA1c, TC, TG, HDL-C, LDL-C, SBP and DBP were significantly increased in T2DM-SCH group (P<0.05) while the levels of cardiac function LVEF and E/A were decreased significantly (P<0.05). There were 31 cases (48.44%) of cardiovascular events in T2DM-SCH group and 76 cases (27.14%) of cardiovascular events in SCH group (χ2=14.752, P=0.005). Conclusions: T2DM can increase the risk of lipid metabolism disorder, cardiac dysfunction, and cardiac adverse events in SCH patients.
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2019, Vol. 25 
