慢性鼻-鼻窦炎患者鼻息肉组织中CD69 RANTES的表达意义研究

doi:10.3969/j.issn.1006-6233.2019.10.023

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Abstract Objective: To investigate the significance of CD69 and RANTES expression in nasal polyps of patients with chronic rhinosinusitis (CRS). Methods: 198 cases of CRS and 87 cases of health examinees (control group) in our hospital were selected. CRS patients were divided into non-nasal polyp group (n=92) and nasal polyp group (n=106). Then the mRNA and protein levels of CD69, RANTES, and levels of IL-4, IL-10, IL-12, IFN-γ, TNF-α, and hs-CRP were measured and compared between groups. Results: The mRNA and protein levels of CD69 and RANTES ranking in a descending order was nasal polyp group, non-nasal polyp group and control group (P<0.05).The levels of IL-4, IL-10, IL-12, TNF-α, and hs-CRP ranking in a descending order was nasal polyp group, non-nasal polyp group and control group (P<0.05).The IFN-γ levels ranking in an ascending order was nasal polyp group, non-nasal polyp group and control group (P<0.05). The mRNA levels of CD69 and RANTES were positively correlated with IL-4, IL-8, IL-10, TNF-α and hs-CRP, and negatively correlated with IFN-γ (P<0.05). High levels of TNF-α, CD69, and RANTES mRNA were risk factors for nasal polyps in CRS patients (P<0.05). The AUC, sensitivity and specificity of CD69 and RANTES mRNA in the diagnosis of CRS were similar (χ²=1.219, 1.695, P>0.05), which were less than TNF-α (P<0.05). Conclusion: Elevated levels of CD69 and RANTES in nasal polyps cause a series of inflammatory factors imbalance, which may be the pathogenesis of CRS; moreover, the high levels of CD69 and RANTES are risk factors for nasal polyps in CRS patients.

Key words： CRS Nasal polyp tissue CD69 RANTES

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	CHEN Xuemei
	YI Shujun
	YANG Li
	et al

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CHEN Xuemei,YI Shujun,YANG Li, et al. Significance of CD69 and RANTES Expression in Nasal Polyps of Patients with Chronic Rhinosinusitis[J]. HeBei Med, 2019, 25(10): 1674-1679.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.10.023 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I10/1674

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