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| Curative efficacy of Qili Qiangxin Capsule Combined with Benazepril in Treatment of Senile Hypertension Complicated with Heart Failure and Regulation Effects on of Neuroendocrine Hormones |
| GUO Shen, LI Xuedi, GUO Hua, et al |
| 983 Hospital of Joint Logistics Support Force, Tianjin 300142, China |
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Abstract Objective: To study the curative efficacy of Qili Qiangxin Capsule combined with Benazepril in treatment of senile hypertension complicated with heart failure and regulation effects on of neuroendocrine hormones. Methods: 104 patients of senile hypertension complicated with heart failure who received therapy from January 2016 to September 2018 in our hospital were selected as research objects, according to simple random number table method, those patients were divided into 54 case of the observation group and the 50 cases of the control group, on the basis of routine treatment, the control group was treated with benazepril, while the observation group was combined with Qili Qiangxin Capsule on the basis of the control group, they were treated for 8 weeks. The clinical efficacy, serum neuroendocrine hormones, blood pressure, cardiac function and adverse reactions were compared between the two groups. Results: After treatment, the total effective rate in the observation group was significantly higher than those in the control group(P<0.05);there were significant differences in the interaction of serum angiotensin Ⅱ (AngⅡ), endothelin-1 (ET-1), norepinephrine (NE), systolic blood pressure (SBP), diastolic blood pressure (DBP), left ventricular ejection fraction (LVEF), left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic diameter (LVEDD), 6-minute walking distance (6MWT) between groups at interblock, different time points, interblock·different time points(P<0.05);there were no obvious adverse reactions during treatment in both groups. Conclusion: Qili Qiangxin Capsule combined with Benazepril is well for senile hypertension complicated with heart failure, which can effectively regulate the expression of serum neuroendocrine hormones, reduce blood pressure, improve cardiac function, and no increase in adverse drug reactions the clinical application value is high.
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2019, Vol. 25 
