甘露醇联合丙种球蛋白对重症手足口病患儿的疗效观察及白细胞计数CRP的影响

doi:10.3969/j.issn.1006-6233.2019.10.017

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Abstract Objective: To study the curative effect of mannitol combined with gamma globulin on children with severe hand, foot and mouth disease and the influence of white blood cell count and C reactive protein (CRP). Methods: 98 cases of hand, foot and mouth disease from February 2014 to February 2018 were selected. According to simple random grouping method, the children were divided into observation group (n=51) and control group (n=47). The control group was treated with gamma globulin, while the observation group was treated with mannitol combined with gamma globulin. The curative effect, clinical symptom subsidence time, white blood cell count, CRP level and the incidence of adverse reactions of the two groups were observed. Results: After treatment, the total effective rate of the observation group was significantly higher than that of the control group [94.11% (48/51) vs 74.46% (35/47)] (P<0.05), and the time of clinical symptoms subsidence was significantly lower than that of the control group [(2.18±0.63) D vs (4.01±0.85) d, (2.41 (+0.65) D vs (5.24 ±1.23) d, (2.90±0.52) D vs (5.86±1.30) d] (P < 0.05). The number and CRP were significantly lower than those of the control group [(10.36±4.62) 10⁹/L vs (10.64±5.09) 10⁹/L, (1.23±0.34) mg/L vs (2.97±0.75) mg/L] (P < 0.05), and the total incidence of adverse reactions was significantly lower than that of the control group [(5.88% (3/51) vs 21.27% (10/47)] (P<0.05). Conclusion: Mannitol combined with gamma globulin in the treatment of children with severe hand, foot and mouth disease has a significant effect. It can effectively improve the clinical symptoms of children with severe hand, foot and mouth disease, reduce the level of white blood cell count and CRP, and is safe and reliable.

Key words： Hand foot mouth disease Mannitol Camma globulin Leukocyte count C-reactive protein Tumor necrosis factor

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	GAO Kuiwu
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Cite this article:

GAO Kuiwu,WANG Chen. Effect of Mannitol combined with Gamma Globulin on Leukocyte count and CRP in Children with Severe Hand-foot-mouth Disease[J]. HeBei Med, 2019, 25(10): 1651-1653.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.10.017 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I10/1651

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