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| Efficacy of Clove Oil Cement combined with Minocycline on Acute Retrograde Pulpitis and The Effect of Inflammatory Factors |
| LUO Lin, LUO Wenping, et al |
| Wuchang Hospital in Wuhan , Hubei Wuhan 430063, China |
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Abstract Objective: To study effect of Clove oil cement combined with minocycline on Acute retrograde pulpitis and the effect of inflammatory factors. Methods: 84 reversible pulpitis admitted from March 2017 to April 2018 in our hospital were selected as research objects. According to random number table, those patients were divided into the observation group (n=45) and the control group (n=39). The control group was treated with Clove oil cement, while the observation group treated with clove oil combined with minocycline. Then the Therapeutic efficacy, tooth mobility, pain score and pain relief time, levels of Leukotriene, tumor necrosis factor, interleukin 8 in gingival crevicular fluid, and incidence of adverse reactions of two groups after treatment were compared. Results: After treatment, The total remission rate in the observation group was significantly higher than that in the control group[93.33%(42/45)vs69.23%(27/39)](P < 0.05). The degree of tooth loosening, the percussion score were significantly lower than those of the control group[(0.82±0.31)branch vs(1.56±0.40)branch,(1.16±0.34)branch vs(2.03±0.56)branch](P＜0.05).The levels of LTB4、TNF-α、IL-8 were significantly lower than those in control group[(15.97±3.76)pg/mL vs(26.49±6.21)pg/mL,(21.02±5.57)mg/L vs(30.27±7.30)mg/L,(7.34±1.39)pg/mL vs(12.90±3.28)pg/mL](P＜0.05). The total incidence of adverse reactions was significantly lower than that of the control group[6.66%(3/45)vs25.64%(10/39)](P＜0.05). Conclusion: Clove oil hydrating combined with minocycline has a significant effect on retrograde pulpitis. It can improve clinical symptoms, relieve pain, reduce the levels of inflammatory factors LTB4, TNF-alpha and IL-8, with fewer complications and is safe and reliable.
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2019, Vol. 25 
