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| The Relationships Between Preoperative Fibrinogen and D-dimer Levels with Prognosis in Patients with Debakey Type I Aortic Dissection |
| SONG Chaoguo, LIU Jian, ZHANG Aimin, et al |
| Handan Central Hospital of Hebei Province, Hebei Handan 056001, China |
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Abstract Objective: To detect the expressions of fibrinogen (FIB) and D-dimer (D-D) in patients with Debakey type I aortic dissection before operation, and to analyze their relationships with adverse prognosis. Methods: 56 patients with Debakey type I aortic dissection admitted to our hospital from January 2015 to December 2017 were retrospectively selected as the study subjects, according to whether death occurred one year after operation, they were divided into 41 cases in survival group and 15 cases in death group, another 40 healthy volunteers were selected as control group, the basic clinical data of the subjects were collected, preoperative plasma FIB and D-D levels were measured by Automatic Coagulation analyzer. Results: Preoperative CRP, SBP, DBP, WBC, PLT, FIB, and D-D levels in the death group were significantly higher than those in the survival group and the control group (P < 0.05), and the survival group were significantly higher than the control group (P < 0.05). The AUC of plasma FIB in predicting the adverse prognosis of Debakey type I aortic dissection was 0.893, sensitivity was 86.70%, and specificity was 85.40%; the AUC of D-D in predicting the adverse prognosis of Debakey type I aortic dissection was 0.810, sensitivity was 80.00%, and specificity was 75.60%; the AUC of FIB combined D-D in predicting the adverse prognosis of Debakey type I aortic dissection was 0.951, sensitivity was 93.30%, and specificity was 97.90%; FIB and D-D levels were independent risk factors for adverse prognosis in patients with Debakey type I aortic dissection (P < 0.05). Conclusion: FIB and D-D are highly expressed in plasma of patients with Debakey type I aortic dissection before operation, it is an independent risk factor for adverse prognosis, the predictive value of the two combined detection for adverse prognosis is higher than that of single index detections.
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2019, Vol. 25 
