阿立哌唑联合舍曲林治疗强迫症患者的疗效及对脑源性神经营养因子TNF IL-2水平的影响

doi:10.3969/j.issn.1006-6233.2019.10.002

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1244 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To study the therapeutic effect of aripiprazole combined with sertraline on obsessive-compulsive disorder and effects of brain-derived neurotrophic factor, tumor necrosis factor (TNF) and interleukin-2 (IL-2). Methods: 82 received therapy from March 2017 to March 2018 in our hospital were selected as research objects. According to random number table,all the patients were divided into the observation group (n=42) and the control group (n=40). The control group was treated with Sertraline, while the observation group treated with Aripiprazole combined with sertraline. Then the Therapeutic efficacy, Yale Brown Obsessive-compulsive Disorder Scale (Y-BOCS) and Hamilton Anxiety Scale (HAMA) score, brain-derived neurotrophic factor, TNF, IL-2 level, incidence of adverse reactions of two groups after treatment were compared. Results: After treatment, The total effective rate of observation group was significantly higher than that of control group[92.85%(39/42)vs 70.00%(28/40)](P＜0.05).Y-BOCS and HAMA scores were significantly lower than those of the control group [(9.86±3.13)scores vs(14.42±4.52)scores,(7.68±2.10)scores vs(12.06±3.09)scores](P＜0.05). The levels of brain-derived neurotrophic factor and TNF were significantly higher than those of the control group [(40.02±5.87)μg/L vs(29.76±4.95)μg/L(38.49±8.98)μg/L vs(34.09±7.34)μg/L](P＜0.05). The level of IL-2 was significantly lower than that of the control group[(50.32±6.28)ng/L vs(62.93±7.59)ng/L](P＜0.05). Conclusion: Aripiprazole combined with sertraline is effective in the treatment of obsessive-compulsive disorder. It can improve the clinical symptoms, regulate the secretion of neurotransmitters in the brain, and improve the levels of brain-derived neurotrophic factor, TNF and IL-2. It is safe and reliable.

Key words： Obsession Aripiprazole Sertraline Brain-derived neurotrophic factor Tumor necrosis factor Interleukin-2

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	BU Qinfang
	CHEN Fangbin

Cite this article:

BU Qinfang,CHEN Fangbin. Effect of Aripiprazole Combined with Sertraline on Obsessive-compulsive Disorder and Effects of Brain-derived Neurotrophic Factor TNF and IL-2[J]. HeBei Med, 2019, 25(10): 1589-1592.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.10.002 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I10/1589

[1] 张力方,牛琪惠,杨磊,等.舍曲林联用丁螺环酮和单用舍曲林治疗强迫症的疗效比较[J].中国新药与临床杂志,2015,34(3):236~238.
[2] Mir T H, Nisar M. Lipstick obsession and red urine[J]. Kidney International, 2018, 94(1):223.
[3] 万其容,胡亚荣,徐金枝,等.舍曲林联合氨磺必利治疗难治性强迫症的临床研究[J].神经损伤与功能重建,2016,11(2):138~140.
[4] Kaul N. India’s obsession with Kashmir: democracy, gender, (anti-)nationalism[J]. Feminist Review, 2018, 119(1):126~143.
[5] 刘英,刘丽清,杨世昌.强迫症的病因及治疗研究进展[J].菏泽医学专科学校学报,2014,26(1):61~63.
[6] 任卫国,张德伦,宋娟,等.帕罗西汀联合阿立哌唑治疗强迫症有效性和安全性的临床疗效研究[J].川北医学院学报,2018,33(4):561~563,582.
[7] 方海亮,郝枭雄,陈统,等.舍曲林联合心理疗法治疗青少年强迫症的临床疗效及安全性评价[J].中国临床药理学杂志,2015,31(19):1937~1939.
[8] Kratz C A. The Case of the recurring wodaabe: visual obsessions in globalizing markets[J]. African Arts, 2018, 51(1):24~45.
[9] 蒋硕,袁茂,曾骥.齐拉西酮胶囊联合舍曲林治疗难治性强迫症的疗效和安全性[J].中国药物与临床,2015,15(6):834~836.
[10] Hanlon G. Violence: a modern obsession by richard bessel[J]. The English Historical Review, 2017, 132(556):776~777.
[11] Dadfar M, Abdel-Khalek A M, Lester D. Validation of the farsi version of the death obsession scale among nurses[J]. International Journal of Nursing Sciences, 2018, 5(2):186~192.
[12] 陶建青,龚冀荣,陆锦滢,等.阿立哌唑增效治疗强迫症疗效与安全性的Meta分析[J].广西医学,2018,40(16):1856~1859,1863.
[13] 郝红,赵宁民,朱雪萍,等.氟伏沙明联合阿立哌唑对强迫症患者临床症状及认知功能的影响[J].国际精神病学杂志,2017,44(2):243~246.
[14] 刘立滢,贾碎林,黄子夜.抑郁症与强迫症合并肺结核患者脑源性神经营养因子及白细胞介素的变化研究[J].中华医院感染学杂志,2015,25(10):2182~2184.
[15] 李欣欣,黄晓艳.帕罗西汀联合阿立哌唑治疗强迫症有效性和安全性的临床疗效观察[J].中国冶金工业医学杂志,2017,34(5):576~578.