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| Study on the Correlation between Background Enhancement of Breast and Molecular Subtypes of Breast Cancer on Magnetic Resonance Imaging |
| ZHU Juan, ZHU Yichun |
| Anqing Municipal Hospital, Anhui Anqing 246003, China |
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Abstract Objective: To investigate the correlation between BPE (Background parenchymal enhancement) and molecular subtypes and common prognostic markers of breast cancer. Methods: A retrospective analysis was made on the clinical data of 60 female patients examined by breast MRI in our hospital from January 2017 to April 2018. All patients were examined by GE MR750 3.0T superconducting magnetic resonance scanning system in the United States, and had complete dynamic enhanced image results. All patients received immunohistochemical tests, including estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2) and Ki-67 index. Pathological and molecular subtype results were analyzed to investigate the correlation between BPE, FGT and molecular subtypes and prognostic markers. Results: 60 cases of breast cancer were classified as invasive ductal carcinoma in 54 cases, intraductal papillary carcinoma in 2 cases and ductal carcinoma in situ in 4 cases. Molecular subtypes: 19 cases of Luminal A, 26 cases of Luminal B, 12 cases of HER-2 overexpression and 3 cases of TNBC. The distribution of BPE and FGT: BPE was BPE 1 (14,23.3%), BPE 2 (27,45%), BPE 3 (12,20%) and BPE 4 (7,11.7%). The distribution of FGT was FGT 1 (2,3.4%), FGT 2 (15,25%) and FGT 3 (23,38.3%) FGT 4 (20,33.3%). The average age of patients with high BPE and FGT was lower than that of patients with low BPE and FGT, and the difference was statistically significant (t value was 3.8, 2.5, P value was 0.008 and 0.01, respectively). The average Ki-67 index was not significantly correlated with BPE and FGT in high and low groups (t value was 6.1, 5.8, P value was 0.45 and 0.43, respectively). The results of correlation analysis showed that there was no correlation between high BPE and FGT in Luminal B, HER-2 overexpression breast cancer and TNBC compared with Luminal A breast cancer (P > 0.05). In the comparison of menstrual status, BPE and FGT in premenopausal patients were higher than those in postmenopausal patients (2 values were 20.5, 18.23, P values were 0.007 and 0.004 respectively). In other prognostic markers, high BPE had no significant correlation with lymph node status, histological grade and Ki-67 expression (P > 0.05). Conclusion:Some patients with poor prognosis, such as HER-2 overexpression breast cancer or TNBC, have no increased risk of BPE. There was no significant correlation between BPE elevation and negative prognostic markers such as positive axillary lymph node, high expression of Ki-67 index and high histological grade.
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2019, Vol. 25 
