结核性胸膜炎患者血清25-(OH)D<sub>3</sub>与IFN-γ IL-10表达的相关性

doi:10.3969/j.issn.1006-6233.2019.09.024

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Abstract Objective: To analyze the correlations between serum 25-hydroxyvitamin D₃ [25-(OH)D₃] with interferon-γ (IFN-γ) and interleukin-10 (IL-10) levels in patients with tuberculous pleurisy and explore its significance. Methods: 73 patients with tuberculous pleurisy who first diagnosed in our hospital from January 2017 to May 2018 were selected as the case group, and 60 another healthy people were as the control group, the levels of serum 25-(OH)D₃, IFN-γ and IL-10 were detected by enzyme-linked immunosorbent assay (ELISA), the correlations between serum 25-(OH)D₃ with IFN-γ and IL-10 were analyzed. Results: The levels of serum 25-(OH)D₃ and IL-10 in the case group were lower than those in the control group (P < 0.05), and the level of serum INF-γ was higher than that in the control group (P < 0.05); the levels of serum 25-(OH)D₃, INF-γ and IL-10 in different stages of tuberculous pleurisy were significantly different (P<0.05); with the aggravation of the disease, the serum 25- (OH) D₃ and IL-10 levels gradually decreased (P < 0.05), the level of INF-γ increased gradually (P < 0.05); the levels o serumf 25-(OH)D₃ and IL-10 were increased (P < 0.05) and INF-γ was decreased (P < 0.05) in the case group after treatment; serum 25-(OH)D₃ was negatively correlated with INF-γ (r=-0.562, P=0.007), and positively correlated with IL-10 (r=0.668, P=0.001) in patients with tuberculous pleurisy. Conclusion: Serum 25-(OH)D₃ level is decreased in patients with tuberculous pleurisy, it is related to the abnormal levels of INF-γ and IL-10, it is suggested that 25-(OH)D₃ deficiency may be an important mechanism of immune dysfunction in tuberculous pleurisy.

Key words： Tuberculous pleurisy 25-hydroxyvitamin D₃ Interferon-γ Interleukin-10

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	GONG Huabin
	ZHANG Wanlin

Cite this article:

GONG Huabin,ZHANG Wanlin. The Correlations Between Serum 25-(OH)D₃ with IFN-γ and IL-10 Levels in Patients with Tuberculous Pleurisy[J]. HeBei Med, 2019, 25(9): 1499-1503.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.09.024 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I9/1499

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