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| Expression of Foxp3 and beta-catenin in Breast Cancer and the Relationship with Clinical Prognosis |
| LI Jun, LANG Xiao'ou |
| The Central Hospital Affiliated to Shenyang Medical College, Liaoning Shenyang 110024, China |
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Abstract Objective: To discuss the expression of forked head / wing like spiral transcription factor (Foxp3) and beta catenin in breast cancer and the relationship with clinical prognosis. Methods: The expression of Foxp3 and beta-catenin in 80 cases of breast cancer and adjacent normal tissues in our hospital from August 2016 to August 2018 was detected by immunohistochemistry. The relationship between the expression of Foxp3 and beta-catenin and pathological characteristics and survival and prognosis of breast cancer was analyzed. Results: The positive rates of Foxp3 and beta-catenin expression in breast cancer tissues were significantly higher than those in adjacent normal tissues, the difference was statistically significant (P < 0.05). The expressions of Foxp3 and beta-catenin in breast cancer tissues were correlated with clinical stage, pathological grade and lymph node metastasis (P < 0.05). The expressions of Foxp3 and beta-catenin in breast cancer tissues were positively correlated (P < 0.05). The survival curve analysis showed that, the 1-year survival rate of patients with positive expression of Foxp3 and beta-catenin was significantly lower than those patients with with negative expression of Foxp3 and beta-catenin, the difference was statistically significant (P < 0.05). Conclusions: Foxp3 and beta-catenin are related to the occurrence and development of breast cancer, and their expressions are positively correlated, suggesting that the detection of their expressions can be used as the important index for evaluating the clinical prognosis of breast cancer.
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2019, Vol. 25 
