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| Effects of Different Doses of Oxycodone After Anesthesia Induction on the Stress Response of Tracheal Intubation and Hemodynamics in Patients with Surgery |
| YIN Junru, ZHAO Jiankui, YANG Yonghui, et al |
| Second Affiliated Hospital of Air Force Military Medical University, Shaanxi Xi'an 710038, China |
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Abstract Objective:To explore the clinical effects of different doses of oxycodone in general anesthesia of surgery. Methods:116 patients with general anesthesia of surgery were selected for the study and were randomly divided into high-dose group and low-dose group, with 58 cases in each group. High-dose group was given 0.3 mg/kg oxycodone after anesthesia induction, and low-dose group was given 0.15 mg/kg oxycodone. Hemodynamics parameters [heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP)] were compared between the two groups before intubation (T0), immediately after tracheal intubation (T1), at 1min after tracheal intubation (T2), at 3min after tracheal intubation (T3) and at 10min after tracheal intubation (T4). The stress response indicators [serum norepinephrine (NE), plasma cortisol (COR), blood glucose (GLU)] were analyzed at T0 and immediately after extubation (T5) in the two groups, and the basic indicators during peri-recovery period and incidence rate of adverse drug reactions within 10min after injection were observed in the two groups. Results:At T1, the levels of HR, SBP and DBP in the two groups were significantly decreased compared with those at T0 (P<0.05), but there were no significant differences between the two groups (P>0.05). At T2 and T3, the levels of HR, SBP and DBP in the two groups were significantly increased compared with those at T0, and the levels in high-dose group were significantly lower than those in low-dose group (P<0.05). At T4, the levels of HR, SBP and DBP in the two groups were significantly decreased compared with those at T0, and the levels in high-dose group were significantly lower than those in low-dose group (P<0.05). At T5, the levels of NE, COR and GLU in the two groups were significantly increased compared with those at T0, and the levels in high-dose group were significantly higher than those in low-dose group (P<0.05). There were no significant differences between the two groups in the spontaneous breathing time, duration of eye opening, duration of fist making and time of returning to the ward during peri-recovery period (P>0.05). Within 10 min after injection, there were no significant differences in the incidence rates of hypotension, glossocoma, bucking and hypercapnia between the two groups (P>0.05). Conclusions: High dose of oxycodone after anesthesia induction can effectively inhibit the stress response of tracheal intubation and promote hemodynamic stability, and it is beneficial to maintain the anesthesia depth suitable for surgical operation.
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2019, Vol. 25 
