|
|
Analysis on Efficacy of Cimetidine and Interferon combined with Zinc Supplement in treatment of Rotavirus Infectious Diarrhea in Children |
WANG Daoli, WANG Qian, HE Aling |
Northwest Women's and Children's Hospital, Shaanxi Xi'an 710061, China |
|
|
Abstract Objective: To study the application effects of cimetidine and interferon combined with zinc supplement in the treatment of rotavirus infectious diarrhea in children. Methods:180 children patients with rotavirus infectious diarrhea admitted to our hospital from January 2017 to January 2018 were randomly divided into observation group (cimetidine + interferon+zinc supplement, n=90) and control group (cimetidine+interferon, n=90). The treatment effects were observed in the two groups. Results:The stool recovery time, dehydration correction time and body temperature recovery time in observation group were significantly shorter than those in control group (P<0.05). After 3 d of treatment, the negative conversion rate of fecal rotavirus antigen in observation group was significantly higher than that in control group (P<0.05), and the effective rate of treatment was significantly better than that in control group (P<0.05). After 10 d of treatment, the blood zinc levels in the two groups were significantly higher than those before treatment (P<0.05), and the increase in observation group was significantly greater than that in control group (P<0.05), and the blood zinc level in observation group after treatment was significantly higher than that in control group (P<0.05). At 3 months of telephone follow-up, the recurrence rate was 8.89% in observation group and was 20.00% in control group, and there was a significant difference in the recurrence rate between the two groups (χ2=4.23, P<0.05). Conclusions: Zinc supplementation with cimetidine and interferon has a good application value in children with RV infectious diarrhea. It can alleviate the clinical symptoms of children in a short time, promote the negative reaction of RV antigen, improve the treatment effect and reduce the recurrence rate in later period. It is worthy of clinical promotion.
|
|
|
|
|
[1] 梁玉彩,周瑞清,孙文琴.小儿感染性腹泻的临床特征及流行病学调查研究[J].中国妇幼保健,2017,32(14):3303~3305. [2] 杨慧,吴莹,朱航.西咪替丁对小儿轮状病毒肠炎的临床疗效分析[J].国际病毒学杂志,2016,23(4):271~273. [3] 古德凤.喜炎平联合干扰素治疗小儿轮状病毒肠炎的临床效果及对外周血中性粒细胞的影响[J].世界中西医结合杂志,2017,12(11):1590~1593. [4] 康春华,叶毅桦,赵炜.小儿轮状病毒肠炎血锌水平变化及补锌治疗[J].昆明医学院学报,2010,31(11):109~113. [5] 梁忠培,杨力,邓昌枢,等.参苓白术散加减辅助推拿辩证治疗小儿急性轮状病毒感染性腹泻的临床疗效研究[J].中华医院感染学杂志,2017,27(22):5262~5265. [6] 冉旭华,刘阳阳.轮状病毒的早期细胞侵入机制[J].中国生物制品学杂志,2017,30(9):986~989. [7] 何雪芳.西咪替丁联合思密达治疗婴幼儿轮状病毒肠炎效果观察[J].现代消化及介入诊疗,2017,22(3):403~405. |
|
|
|