有创-无创序贯机械通气治疗创伤性ARDS的临床疗效及对患者血清中NT-proBNP和炎症因子水平的影响

doi:10.3969/j.issn.1006-6233.2019.08.016

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Abstract Objective: To observe the clinical curative effect of invasive-noninvasive sequential mechanical ventilation on traumatic acute respiratory distress syndrome (ARDS) and the influences levels of serum N-terminal pro-B-type natriuretic peptide (NT-proBNP) and inflammatory factors in serum. Methods: 96 patients with traumatic ARDS who were admitted to the hospital and needed mechanical ventilation from October 2016 to October 2018 were randomly divided into 2 groups, 48 cases in each group. Group A was given invasive-noninvasive sequential mechanical ventilation, while group B was given simple invasive mechanical ventilation. The blood gas analysis indexes before and at 24h after treatment, levels of serum NT-proBNP and inflammatory factors [interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-α)] before and at 3d after treatment were compared between the 2 groups. The indexes of mechanical ventilation and conditions after weaning in the 2 groups were observed. Results: The blood pH, PaCO₂ and PaO₂ in the 2 groups were significantly improved at 24h after treatment (P<0.05), There was no significant difference in the above indexes between the two groups before and after treatment (P>0.05). The difference values of serum NT-proBNP, IL-6 and TNF-α levels before and after treatment in group A were significantly higher than those in group B (P<0.05). The total ventilation time, invasive ventilation time and length of stay in ICU of group A were significantly shorter than those of group B, and the incidence of VAP was significantly lower than that in group B (P<0.05). Conclusion: The invasive-noninvasive sequential mechanical ventilation can effectively improve blood gas indexes, relieve heart injury and inflammation, decreased incidence of VAP and shorten the rehabilitation process of patients with traumatic ARDS.

Key words： Invasive-noninvasive Sequential mechanical ventilation Traumatic Acute respiratory distress syndrome Inflammatory factors

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	WANG Xinfeng
	YANG Aizhen
	DING Zhaoyong
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Cite this article:

WANG Xinfeng,YANG Aizhen,DING Zhaoyong, et al. Clinical Efficacy of Invasive-noninvAsive sequential Mechanical Ventilation in the treatment of Traumatic ARDS and its Effect on Serum NT-proBNP and Inflammatory Factors[J]. HeBei Med, 2019, 25(8): 1291-1294.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.08.016 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I8/1291