单磷酸阿糖腺苷联合普米克令舒对毛细支气管炎患儿的疗效及对血清LTE4 MCP-1 INF-γ的影响

doi:10.3969/j.issn.1006-6233.2019.08.013

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Abstract Objective: To study Curative efficacy of Vidarabine monophosphate combined with primeresch in treatment of Children with bronchiolitis and its effectson serum Leukotriene E4 (LTE4), monocyte chemokinin-1 (McP-1), interferon-gamma (inf-gamma). Methods: 90 children with bronchiolitis treated in our hospital from February 2015 to February 2017 was conducted, they were randomly divided into observation group (n=48) and control group (n=42). The observation group was treated with adenosine monophosphate combined with pulmicort respules. The control group was treated with pulmicort respules. The clinical efficacy, serum LTE4, McP-1, inf-gamma, TNF- alpha, interleukin-6 (il-6), interleukin-8 (il-8), time of disappearance of clinical symptoms and adverse reactions in the two groups were compared. Results: The effective rate of the observation group was 95.83%, significantly higher than that of the control group (80.95%, P<0.05). After treatment, serum LTE4, McP-1 and inf-gamma levels were significantly improved in the two groups (P<0.05). Serum LTE4 and McP-1 levels in the observation group were lower than those in the control group, and inf-gamma levels were significantly higher than those in the control group (P<0.05). After treatment, serum tnf-alpha, il-6 and il-8 levels were significantly improved in both groups (P<0.05). Serum tnf-alpha, il-6 and il-8 levels in the observation group were lower than those in the control group (P<0.05). The time of antipyretic, time of disappearance of moist rale, time of disappearance of wheezing, time of disappearance of cough and time of hospitalization in the observation group was significantly lower than that in the control group (P<0.05). The total incidence of rash, nausea, diarrhea and angioedema in the two groups was 8.33% and 16.67%, respectively, with no statistically significant difference (P>0.05). Conclusion: The efficacy of adenosine monophosphate combined with pramikacin in the treatment of bronchiolitis in children is relatively high, which can effectively improve the serum LTE4, McP-1 and inf-gamma levels in patients with less adverse reactions, and the children are basically tolerable and worthy of popularization and application.

Key words： Bronchitis Adenosine monophosphate Pulmicort respules Leukotriene E4 Monocyte chemokinin-1 Interferon gamma

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CHAO Yujin. Effects of Adenosine Monophosphate combined with Pulmicort Respules on Serum LTE4, MCP-1 and INF-gamma in Children with Bronchiolitis[J]. HeBei Med, 2019, 25(8): 1280-1283.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.08.013 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I8/1280

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