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| Effects of Gefitinib Targeted Therapy on Epidermal Growth Factor and Immune Function in Patients with Non-small Cell Lung Cancer |
| XU Haifeng, DONG Yuchao, QIN Hao, et al |
| Shaxi Branch of Shanghai 10th People's Hospital, Shanghai 215421, China |
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Abstract Objective: To study the effects of gefitinib targeted therapy on epidermal growth factor and immune function in patients with late stage EGFR gene mutation non-small cell lung cancer (NSCLC). Methods: 120 patients with late stage EGFR gene mutation NSCLC who were admitted to the hospital from January 2016 to August 2017 were selected and divided into control group and observation group according to simple random grouping method. Control group was given conventional chemotherapy regimen, and observation group was given gefitinib on the basis of control group, and they were treated for 4 cycles with a cycle of 28d. The efficacy, incidence rate of toxic and side effects of III and IV chemotherapy were counted in the two groups. The levels of T lymphocytes, immunoglobulins, serum and pleural effusion EGFR were detected. Results: The disease control rate and effective rate of treatment in observation group were higher than those in control group (P<0.05). The CD3+, CD4+ and CD4+/CD8+ levels in observation group after treatment were higher than those in control group while the CD8+ level was lower than that in control group (P<0.05). The immunoglobulins indexes in observation group after treatment were higher than those in control group (P<0.05). The levels of epidermal growth factor receptor (EGFR) in serum and pleural effusion after treatment in observation group were lower than those in control group (P<0.05). Conclusions: Gefitinib targeted therapy can significantly reduce EGFR level and improve immune function in the treatment of late stage EGFR gene mutation NSCLC.
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2019, Vol. 25 
